Abstract
The functional role of an adherent cell in assisting a variety of in vitro immune responses is well established. An assay for human monocyte chemotaxis in vitro was utilized as a means of investigating the role of adherent cells in the production of the monocyte chemotactic factor that is produced by peripheral blood lymphocytes upon stimulation with Concanavalin A. Depletion of a population of adherent cells by passage of peripheral blood mononuclear cells through a Sephadex G-10 column rendered the latter incapable of producing monocyte chemotactic factor. The requirement for adherent cells in the production of a 'lymphokine' is in agreement with many previous works of a similar nature performed in other experimental systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 273-276 |
| Number of pages | 4 |
| Journal | Immunology Letters |
| Volume | 3 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1981 |
| Externally published | Yes |
Keywords
- adherent cells
- chemotaxis
- lymphokines
- Sephadex G-10 column filtration
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
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Cite this
Vogel, J. E., Pahwa, S. G., Smithwick, E. M., & Good, R. A. (1981). The role of an adherent cell in the production of monocyte chemotactic factor. Immunology Letters, 3(5), 273-276. https://doi.org/10.1016/0165-2478(81)90004-3