The role of an adherent cell in the production of monocyte chemotactic factor

James E. Vogel, Savita G. Pahwa, Elizabeth M. Smithwick, Robert A. Good

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The functional role of an adherent cell in assisting a variety of in vitro immune responses is well established. An assay for human monocyte chemotaxis in vitro was utilized as a means of investigating the role of adherent cells in the production of the monocyte chemotactic factor that is produced by peripheral blood lymphocytes upon stimulation with Concanavalin A. Depletion of a population of adherent cells by passage of peripheral blood mononuclear cells through a Sephadex G-10 column rendered the latter incapable of producing monocyte chemotactic factor. The requirement for adherent cells in the production of a 'lymphokine' is in agreement with many previous works of a similar nature performed in other experimental systems.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalImmunology Letters
Volume3
Issue number5
DOIs
StatePublished - Nov 1981
Externally publishedYes

Keywords

  • adherent cells
  • chemotaxis
  • lymphokines
  • Sephadex G-10 column filtration

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The role of an adherent cell in the production of monocyte chemotactic factor'. Together they form a unique fingerprint.

  • Cite this