The reverse metabolic syndrome in the elderly: Is it a “catabolic” syndrome?

Francesco Curcio, Giuseppe Sasso, Ilaria Liguori, Gaetana Ferro, Gennaro Russo, Michele Cellurale, David Della Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Traditional risk factors of cardiovascular death in the general population, including body mass index (BMI), serum cholesterol, and blood pressure are also found to relate to outcomes in the geriatric population, but in a differing direction. A higher body mass index, hypercholesterolemia and hypertension are not harmful but even permit better survival at advancing age. This phenomenon is called “reverse epidemiology” or “risk factor paradox” and is also detected in a variety of chronic disease states such as chronic heart failure. Accordingly, a low BMI, blood pressure and cholesterol values are associated with a worse prognosis. Several possible causes are hypothesized to explain this elderly paradox, but this phenomenon remains controversial and its underlying reasons are poorly understood. The aim of this review is to recognize the factors behind this intriguing phenomenon and analyse the consequences that it can bring in the management of the cardiovascular therapy in elderly patient. Finally, a new phenotype identified as “catabolic syndrome” has been postulated.

Original languageEnglish (US)
Pages (from-to)547-554
Number of pages8
JournalAging clinical and experimental research
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

Fingerprint

Body Mass Index
Cholesterol
Blood Pressure
Hypercholesterolemia
Geriatrics
Population
Epidemiology
Chronic Disease
Heart Failure
Hypertension
Phenotype
Survival
Serum
Therapeutics
Direction compound

Keywords

  • Blood pressure
  • Body mass index
  • Catabolic syndrome
  • Cholesterol
  • Reverse epidemiology

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Curcio, F., Sasso, G., Liguori, I., Ferro, G., Russo, G., Cellurale, M., ... Abete, P. (2018). The reverse metabolic syndrome in the elderly: Is it a “catabolic” syndrome? Aging clinical and experimental research, 30(6), 547-554. https://doi.org/10.1007/s40520-017-0815-7

The reverse metabolic syndrome in the elderly : Is it a “catabolic” syndrome? / Curcio, Francesco; Sasso, Giuseppe; Liguori, Ilaria; Ferro, Gaetana; Russo, Gennaro; Cellurale, Michele; Della Morte, David; Gargiulo, Gaetano; Testa, Gianluca; Cacciatore, Francesco; Bonaduce, Domenico; Abete, Pasquale.

In: Aging clinical and experimental research, Vol. 30, No. 6, 01.06.2018, p. 547-554.

Research output: Contribution to journalReview article

Curcio, F, Sasso, G, Liguori, I, Ferro, G, Russo, G, Cellurale, M, Della Morte, D, Gargiulo, G, Testa, G, Cacciatore, F, Bonaduce, D & Abete, P 2018, 'The reverse metabolic syndrome in the elderly: Is it a “catabolic” syndrome?', Aging clinical and experimental research, vol. 30, no. 6, pp. 547-554. https://doi.org/10.1007/s40520-017-0815-7
Curcio, Francesco ; Sasso, Giuseppe ; Liguori, Ilaria ; Ferro, Gaetana ; Russo, Gennaro ; Cellurale, Michele ; Della Morte, David ; Gargiulo, Gaetano ; Testa, Gianluca ; Cacciatore, Francesco ; Bonaduce, Domenico ; Abete, Pasquale. / The reverse metabolic syndrome in the elderly : Is it a “catabolic” syndrome?. In: Aging clinical and experimental research. 2018 ; Vol. 30, No. 6. pp. 547-554.
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