The resting brain: Unconstrained yet reliable

Zarrar Shehzad, A. M C Kelly, Philip T. Reiss, Dylan G. Gee, Kristin Gotimer, Lucina Q Uddin, Sang Han Lee, Daniel S. Margulies, Amy Krain Roy, Bharat B. Biswal, Eva Petkova, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalArticle

586 Citations (Scopus)

Abstract

Recent years have witnessed an upsurge in the usage of resting-state functional magnetic resonance imaging (fMRI) to examine functional connectivity (fcMRI), both in normal and pathological populations. Despite this increasing popularity, concerns about the psychologically unconstrained nature of the "resting-state" remain. Across studies, the patterns of functional connectivity detected are remarkably consistent. However, the test-retest reliability for measures of resting state fcMRI measures has not been determined. Here, we quantify the test-retest reliability, using resting scans from 26 participants at 3 different time points. Specifically, we assessed intersession (>5 months apart), intrasession (<1 h apart), and multiscan (across all 3 scans) reliability and consistency for both region-of-interest and voxel-wise analyses. For both approaches, we observed modest to high reliability across connections, dependent upon 3 predictive factors: 1) correlation significance (significantly nonzero > nonsignificant), 2) correlation valence (positive > negative), and 3) network membership (default mode > task positive network). Short- and long-term measures of the consistency of global connectivity patterns were highly robust. Finally, hierarchical clustering solutions were highly reproducible, both across participants and sessions. Our findings provide a solid foundation for continued examination of resting state fcMRI in typical and atypical populations.

Original languageEnglish (US)
Pages (from-to)2209-2229
Number of pages21
JournalCerebral Cortex
Volume19
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

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Reproducibility of Results
Brain
Population
Cluster Analysis
Magnetic Resonance Imaging

Keywords

  • FMRI
  • Intraclass correlations
  • Reliability
  • Resting-state functional connectivity
  • Test-retest

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Cite this

Shehzad, Z., Kelly, A. M. C., Reiss, P. T., Gee, D. G., Gotimer, K., Uddin, L. Q., ... Milham, M. P. (2009). The resting brain: Unconstrained yet reliable. Cerebral Cortex, 19(10), 2209-2229. https://doi.org/10.1093/cercor/bhn256

The resting brain : Unconstrained yet reliable. / Shehzad, Zarrar; Kelly, A. M C; Reiss, Philip T.; Gee, Dylan G.; Gotimer, Kristin; Uddin, Lucina Q; Lee, Sang Han; Margulies, Daniel S.; Roy, Amy Krain; Biswal, Bharat B.; Petkova, Eva; Castellanos, F. Xavier; Milham, Michael P.

In: Cerebral Cortex, Vol. 19, No. 10, 10.2009, p. 2209-2229.

Research output: Contribution to journalArticle

Shehzad, Z, Kelly, AMC, Reiss, PT, Gee, DG, Gotimer, K, Uddin, LQ, Lee, SH, Margulies, DS, Roy, AK, Biswal, BB, Petkova, E, Castellanos, FX & Milham, MP 2009, 'The resting brain: Unconstrained yet reliable', Cerebral Cortex, vol. 19, no. 10, pp. 2209-2229. https://doi.org/10.1093/cercor/bhn256
Shehzad Z, Kelly AMC, Reiss PT, Gee DG, Gotimer K, Uddin LQ et al. The resting brain: Unconstrained yet reliable. Cerebral Cortex. 2009 Oct;19(10):2209-2229. https://doi.org/10.1093/cercor/bhn256
Shehzad, Zarrar ; Kelly, A. M C ; Reiss, Philip T. ; Gee, Dylan G. ; Gotimer, Kristin ; Uddin, Lucina Q ; Lee, Sang Han ; Margulies, Daniel S. ; Roy, Amy Krain ; Biswal, Bharat B. ; Petkova, Eva ; Castellanos, F. Xavier ; Milham, Michael P. / The resting brain : Unconstrained yet reliable. In: Cerebral Cortex. 2009 ; Vol. 19, No. 10. pp. 2209-2229.
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