The response of the kidney of the freshwater rainbow trout to true metabolic acidosis.

K. A. Kobayashi, C. M. Wood

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Infusion of lactic acid into the bloodstream of trout produced a short-lived depression of blood pH and a long-lasting elevation of blood lactate. The lactate injected was distributed in a volume of 198 ml/kg. Renal excretion of lactate anion and total acid increased by approximately equal amounts during the period of high blood lactate levels, but total renal loss over 72 h accounted for only 2% of the lactate load and 6% of the proton load. Comparable differences in the time courses of blood lactate and pH changes occurred when lactacidosis was induced endogenously by normocapnic hypoxia. The immediate response of the kidney was similar to that with lactic acid infusion, but there was a long-lasting (12-72 + h) elevation of urinary acid efflux that was not associated with lactate excretion. Following hypoxia, renal excretion over 72 h accounted for 1% of the estimated lactate load and 12-25% of the proton load. A renal lactate threshold of 4-10 muequiv/ml prevents significant urinary lactate excretion. The response of the trout kidney to true metabolic acidosis is similar to that of the mammalian kidney.

Original languageEnglish
Pages (from-to)227-244
Number of pages18
JournalJournal of Experimental Biology
Volume84
StatePublished - Feb 1 1980

Fingerprint

Oncorhynchus mykiss
acidosis
Acidosis
Fresh Water
excretion
rainbow
lactates
Lactic Acid
blood
kidneys
Kidney
acid
hypoxia
anion
Trout
lactic acid
trout
protons
Protons
blood pH

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

The response of the kidney of the freshwater rainbow trout to true metabolic acidosis. / Kobayashi, K. A.; Wood, C. M.

In: Journal of Experimental Biology, Vol. 84, 01.02.1980, p. 227-244.

Research output: Contribution to journalArticle

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