The response of retinal vasculature to angiotensin

E. J. Rockwood, F. Fantes, E. B. Davis, D. R. Anderson

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


A retinal arterial constriction was produced in anesthetized cats with a continuous transvitreal infusion of angiotensin I or angiotensin II (Ile-5). Constriction of vessels near the infusion cannula tip occurred over a range of angiotensin II concentrations from 10-9 to 10-4 molar, and was reversibly blocked by a ten-fold excess of the competitive antagonist saralasin. Constriction did not occur in response to angiotensin I if angiotensin-converting enzyme was blocked with Captopril. Control infusions of saline did not elicit a contraction of the retinal arteries. Severe axonal and inner retinal damage and necrosis occurred when angiotensin II produced a prolonged vasospasm, but not after infusion with control solutions, or when constriction caused by angiotensin was brief.

Original languageEnglish (US)
Pages (from-to)676-682
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1987

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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