The response of normal rat hepatocytes when exposed to humoral (regenerating) factor

Joe U. Levi; Robert Zeppa

doi:10.1016/0022-4804(72)90130-8

The response of normal rat hepatocytes when exposed to humoral (regenerating) factor

Joe U. Levi, Robert Zeppa

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Evidence for the existence and source of a humoral factor which initiates and controls hepatic regeneration have been reviewed. Collections of this humoral factor have been made by perfusing 24-hour regenerating rat livers. An assay system for this humoral factor has been described which is based on perfusing isolated normal rat livers with the humoral factor, looking for an increase in hepatic DNA synthesis. Autoradiographic studies have revealed that the cells which are synthesizing new DNA in preparation for cell divison are mainly hepatic parenchymal cells (plus an occasional biliary ductal cell) located in all the liver lobules with a distribution primarily in the periportal areas-following the direction of portal and hepatic inflow.

Original language	English (US)
Pages (from-to)	114-119
Number of pages	6
Journal	Journal of Surgical Research
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0022-4804(72)90130-8
State	Published - Feb 1972
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(72)90130-8

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title = "The response of normal rat hepatocytes when exposed to humoral (regenerating) factor",

abstract = "Evidence for the existence and source of a humoral factor which initiates and controls hepatic regeneration have been reviewed. Collections of this humoral factor have been made by perfusing 24-hour regenerating rat livers. An assay system for this humoral factor has been described which is based on perfusing isolated normal rat livers with the humoral factor, looking for an increase in hepatic DNA synthesis. Autoradiographic studies have revealed that the cells which are synthesizing new DNA in preparation for cell divison are mainly hepatic parenchymal cells (plus an occasional biliary ductal cell) located in all the liver lobules with a distribution primarily in the periportal areas-following the direction of portal and hepatic inflow.",

author = "Levi, {Joe U.} and Robert Zeppa",

note = "Funding Information: From the nepart,ment of Surgery, University of Miami School of Medicine and Affiliated Hospitals, Riscayne Annex, Miami, Florida 33152. Supported by National Institutes of Health Grant 5 TOI GM 01683. Submitted for publication November 19, 1971.",

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AU - Levi, Joe U.

AU - Zeppa, Robert

N1 - Funding Information: From the nepart,ment of Surgery, University of Miami School of Medicine and Affiliated Hospitals, Riscayne Annex, Miami, Florida 33152. Supported by National Institutes of Health Grant 5 TOI GM 01683. Submitted for publication November 19, 1971.

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N2 - Evidence for the existence and source of a humoral factor which initiates and controls hepatic regeneration have been reviewed. Collections of this humoral factor have been made by perfusing 24-hour regenerating rat livers. An assay system for this humoral factor has been described which is based on perfusing isolated normal rat livers with the humoral factor, looking for an increase in hepatic DNA synthesis. Autoradiographic studies have revealed that the cells which are synthesizing new DNA in preparation for cell divison are mainly hepatic parenchymal cells (plus an occasional biliary ductal cell) located in all the liver lobules with a distribution primarily in the periportal areas-following the direction of portal and hepatic inflow.

AB - Evidence for the existence and source of a humoral factor which initiates and controls hepatic regeneration have been reviewed. Collections of this humoral factor have been made by perfusing 24-hour regenerating rat livers. An assay system for this humoral factor has been described which is based on perfusing isolated normal rat livers with the humoral factor, looking for an increase in hepatic DNA synthesis. Autoradiographic studies have revealed that the cells which are synthesizing new DNA in preparation for cell divison are mainly hepatic parenchymal cells (plus an occasional biliary ductal cell) located in all the liver lobules with a distribution primarily in the periportal areas-following the direction of portal and hepatic inflow.

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The response of normal rat hepatocytes when exposed to humoral (regenerating) factor

Abstract

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