The relationship of nutritional copper to the development of postmenopausal osteoporosis in rats

Cindy D. Yee, Karen S. Kubena, Michael Walker, Thomas H. Champney, H. Wayne Sampson

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Factors that influence tissue copper concentration include age, diet, hormones, and pregnancy. In this study we altered diet independently, hormone (estrogen) independently, and various combinations of diet and hormone in animals of the same age to study the effects of ovariectomy complicated with dietary copper deficiency; a deficiency that has been demonstrated to cause bone defects. Sprague-Dawley rats were placed on various combinations of copper deficient or enriched diets before and /or after ovariectomy to determine if copper deficiency aggravated osteoporosis and if return to a copper-adequate diet alleviated it. In this study, ovariectomy did induce an osteopenia that was characterized by decreased trabecular bone. This osteopenia was slightly more severe with copper deficiency, but was not necessarily alleviated by the return of normal copper levels to the diet.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBiological Trace Element Research
Volume48
Issue number1
DOIs
StatePublished - Apr 1 1995
Externally publishedYes

Keywords

  • bone development
  • copper
  • Osteopenia
  • osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry, medical
  • Inorganic Chemistry
  • Clinical Biochemistry
  • Biochemistry

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