The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment

Dominique L. Musselman, Dwight L. Evans, Chartes B. Nemeroff

Research output: Contribution to journalReview articlepeer-review

1324 Scopus citations


This article reviews the burgeoning literature on the relationship of mood disorders and heart disease. Major depression and depressive symptoms, although commonly encountered in medical populations, are frequently underdiagnosed and undertreated in patients with cardiovascular disease (CVD). This is of particular importance because several studies have shown depression and its associated symptoms to be a major risk factor for both the development of CVD and death after an index myocardial infarction. This review of the extant literature is derived from MEDLINE searches (1966-1997) using the search terms 'major depression,' 'psychiatry,' 'cardiovascular disease,' and 'pathophysiology.' Studies investigating pathophysiological alterations related to CVD in depressed patients are reviewed. The few studies on treatment of depression in patients with CVD are also described. Treatment of depression in patients with CVD improves their dysphoria and other signs and symptoms of depression, improves quality of life, and perhaps even increases longevity. Recommendations for future research are proposed.

Original languageEnglish (US)
Pages (from-to)580-592
Number of pages13
JournalArchives of General Psychiatry
Issue number7
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


Dive into the research topics of 'The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment'. Together they form a unique fingerprint.

Cite this