The relationship between serum human immunodeficiency virus type 1 (HIV- 1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1- infected children

Lynne M. Mofenson, James Korelitz, William A. Meyer, James Bethel, Kenneth Rich, Savita G Pahwa, John Moye, Robert Nugent, Jennifer Read

Research output: Contribution to journalArticle

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Abstract

Association of human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 cell percent, and mortality was examined in stored sera from 254 infected children in an intravenous immunoglobulin infection prophylaxis trial. Ninety-two children (36.2%) died (41 during the study, 51 during long-term follow-up). The geometric mean baseline HIV-1 RNA level was 104,626 copies/mL, and the mean CD4 cell percent was 25%. Relative risk of death (RR) was 2.1 if the baseline RNA level was >100,000 copies/mL (95% confidence interval [CI], 1.4-3.0) and was 3.0 if the baseline CD4 cell percent was <15% (95% CI, 2.2-4.0). If RNA levels increased after baseline, the RR was 1.8 (95% CI, 1.3-2.6), and if the CD4 cell percent dropped to <15%, the RR was 2.8 (95% CI, 1.6-4.9). In a multivariate model, both baseline RNA level and CD4 cell percent were independently associated with mortality risk. In a time-dependent model, the RR per log10 increase in HIV-1 RNA copy numbers was 2.8 (95% CI, 2.1-3.6) and per 5 percentage point decrement in CD4 cell percent was 1.3 (95% CI, 1.2-1.5). Both variables should be considered for in decision-making regarding therapy and evaluation of antiretroviral response.

Original languageEnglish
Pages (from-to)1029-1038
Number of pages10
JournalJournal of Infectious Diseases
Volume175
Issue number5
StatePublished - May 6 1997
Externally publishedYes

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HIV-1
Lymphocytes
RNA
Confidence Intervals
Mortality
Serum
Intravenous Immunoglobulins
Decision Making
Infection
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The relationship between serum human immunodeficiency virus type 1 (HIV- 1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1- infected children. / Mofenson, Lynne M.; Korelitz, James; Meyer, William A.; Bethel, James; Rich, Kenneth; Pahwa, Savita G; Moye, John; Nugent, Robert; Read, Jennifer.

In: Journal of Infectious Diseases, Vol. 175, No. 5, 06.05.1997, p. 1029-1038.

Research output: Contribution to journalArticle

Mofenson, Lynne M. ; Korelitz, James ; Meyer, William A. ; Bethel, James ; Rich, Kenneth ; Pahwa, Savita G ; Moye, John ; Nugent, Robert ; Read, Jennifer. / The relationship between serum human immunodeficiency virus type 1 (HIV- 1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1- infected children. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 5. pp. 1029-1038.
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