TY - JOUR
T1 - The relationship between Positive and Negative Syndrome Scale (PANSS) schizophrenia severity scores and risk for hospitalization
T2 - An analysis of the CATIE Schizophrenia Trial
AU - Glick, Henry A.
AU - Li, Pengxiang
AU - Harvey, Philip D.
N1 - Funding Information:
CATIE Sz was a National Institute of Mental Health (NIMH)-supported multisite trial comparing the effectiveness of randomly assigned antipsychotic medication treatment for patients with chronic schizophrenia in typical settings and populations ( Stroup et al., 2003 ). The study was supported by NIMH Contract #N01MH90001 to the University of North Carolina at Chapel Hill. Its ClinicalTrials.gov identifier is NCT00014001 . The primary results of the study ( Lieberman et al., 2005 ) plus other analyses have previously been published.
Funding Information:
This research was funded by a Sponsored Research Agreement between the Trustees of the University of Pennsylvania and Alkermes, Inc. The authors were free to analyze the data using any methods they deemed appropriate and to publish, present, or otherwise disclose any research results of the study.
Publisher Copyright:
© 2015 Elsevier B.V.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2015/3/9
Y1 - 2015/3/9
N2 - Background: Little is known about the effect of treatment-related changes in Positive and Negative Syndrome Scale (PANSS) schizophrenia severity scores on the risk for subsequent hospitalization. Methods: We used limited-access data from the Clinical Antipsychotic Trials of Intervention Effectiveness Project Schizophrenia Trial (CATIE Sz) to evaluate the relationship between baseline and changes in PANSS clinical symptom scores and risks for subsequent psychiatric hospitalization. Results: Reductions in PANSS total scores during a three-month period were associated with a significantly lower risk for psychiatric hospitalization (OR, 0.78, 95% CI, 0.72 to 0.84, p < 0.001 for 10 point reductions). Ten-point reductions in PANSS total score during three months reduced predicted number of psychiatric hospitalizations by 0.02 (95% CI, 0.012 to 0.027) and nights in the hospital by 0.24 (95% CI, 0.07 to 0.41). Maintenance of this reduction for a year is expected to reduce psychiatric hospitalizations by 0.10 (95% CI, 0.08 to 0.13) and nights hospitalized by 1.4 (95% CI, 0.9 to 1.9). A 10-point reduction in PANSS total score was associated with a savings in psychiatric hospitalization cost of $192 over three months and $1135 over a year. Conclusions: Reductions in PANSS total scores significantly reduced risks for psychiatric hospitalizations, total number of psychiatric hospitalizations, total nights for psychiatric admissions, and the costs of these hospitalizations. These data highlight the benefits of symptom control on the direct costs of care in schizophrenia.
AB - Background: Little is known about the effect of treatment-related changes in Positive and Negative Syndrome Scale (PANSS) schizophrenia severity scores on the risk for subsequent hospitalization. Methods: We used limited-access data from the Clinical Antipsychotic Trials of Intervention Effectiveness Project Schizophrenia Trial (CATIE Sz) to evaluate the relationship between baseline and changes in PANSS clinical symptom scores and risks for subsequent psychiatric hospitalization. Results: Reductions in PANSS total scores during a three-month period were associated with a significantly lower risk for psychiatric hospitalization (OR, 0.78, 95% CI, 0.72 to 0.84, p < 0.001 for 10 point reductions). Ten-point reductions in PANSS total score during three months reduced predicted number of psychiatric hospitalizations by 0.02 (95% CI, 0.012 to 0.027) and nights in the hospital by 0.24 (95% CI, 0.07 to 0.41). Maintenance of this reduction for a year is expected to reduce psychiatric hospitalizations by 0.10 (95% CI, 0.08 to 0.13) and nights hospitalized by 1.4 (95% CI, 0.9 to 1.9). A 10-point reduction in PANSS total score was associated with a savings in psychiatric hospitalization cost of $192 over three months and $1135 over a year. Conclusions: Reductions in PANSS total scores significantly reduced risks for psychiatric hospitalizations, total number of psychiatric hospitalizations, total nights for psychiatric admissions, and the costs of these hospitalizations. These data highlight the benefits of symptom control on the direct costs of care in schizophrenia.
KW - CATIE Sz
KW - Hospitalization
KW - Psychiatric Status Rating Scales
KW - Schizophrenia
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U2 - 10.1016/j.schres.2015.05.021
DO - 10.1016/j.schres.2015.05.021
M3 - Article
C2 - 26044113
AN - SCOPUS:84955364262
VL - 166
SP - 110
EP - 114
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -