The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly

Xiaoyan Sun, Rafeeque Bhadelia, Elizabeth Liebson, Peter Bergethon, Marshal Folstein, Jay Jiguang Zhu, D. Mkaya Mwamburi, Samuel Patz, Wei Qiao Qiu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background The ratio of high amyloid-β peptide40 (Aβ40) and low Aβ42 in plasma predicts the risk of Alzheimer's disease (AD) and is associated with episodic recall in depression. We thus examined the relationship between plasma Aβ levels and brain volumes. Methods Homebound elders (N = 352) who had undergone brain MRI were used. Plasma Aβ1-40 and Aβ1-42 were measured by ELISA. Volumes of medial temporal regions, including the amygdala and hippocampus, were manually measured. Results Amygdala volume was associated with log10 of plasma Aβ1-42 (β = +0.19, SE = 0.07, p = 0.005) after adjusting for AD, infarcts, white matter hyperintensities and demographics. In the absence of dementia, decreasing quartiles of plasma Aβ1-42 (Mean + SD ml: Q4 = 4.1 ± 0.8; Q3 = 3.9 ± 0.7; Q2 = 3.6 ± 0.8 and Q1 = 3.7 ± 0.8, p = 0.01) and increasing quartiles of plasma Aβ1-40/1-42 ratio were associated with smaller amygdala volume. Those depressed subjects with a high plasma Aβ1-40/1-42 ratio had smaller amygdala (Mean + SD ml: 3.3 ± 0.8 vs. 3.6 ± 0.8, p = 0.04) and total brain volume (Mean + SD liter: 0.95 ± 0.07 vs. 1.04 ± 0.12, p = 0.005), and had a higher rate of MCI (67 vs. 36%, p = 0.02) than those with a low plasma Aβ1-40/1-42 ratio. Conclusions The combination of low plasma Aβ1-42 concentration and atrophy of the medial temporal lobe structures, which regulates mood and cognition, may represent a biomarker for a prodromal stage of AD.

Original languageEnglish (US)
Pages (from-to)593-601
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Volume26
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Temporal Lobe
Amyloid
Peptides
Amygdala
Alzheimer Disease
Brain
Prodromal Symptoms
Cognition
Atrophy
Dementia
Hippocampus
Biomarkers
Enzyme-Linked Immunosorbent Assay
Demography
Depression

Keywords

  • amygdala
  • amyloid-β peptide
  • depression and Alzheimer's disease
  • hippocampus

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly. / Sun, Xiaoyan; Bhadelia, Rafeeque; Liebson, Elizabeth; Bergethon, Peter; Folstein, Marshal; Zhu, Jay Jiguang; Mwamburi, D. Mkaya; Patz, Samuel; Qiu, Wei Qiao.

In: International Journal of Geriatric Psychiatry, Vol. 26, No. 6, 06.2011, p. 593-601.

Research output: Contribution to journalArticle

Sun, X, Bhadelia, R, Liebson, E, Bergethon, P, Folstein, M, Zhu, JJ, Mwamburi, DM, Patz, S & Qiu, WQ 2011, 'The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly', International Journal of Geriatric Psychiatry, vol. 26, no. 6, pp. 593-601. https://doi.org/10.1002/gps.2568
Sun, Xiaoyan ; Bhadelia, Rafeeque ; Liebson, Elizabeth ; Bergethon, Peter ; Folstein, Marshal ; Zhu, Jay Jiguang ; Mwamburi, D. Mkaya ; Patz, Samuel ; Qiu, Wei Qiao. / The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly. In: International Journal of Geriatric Psychiatry. 2011 ; Vol. 26, No. 6. pp. 593-601.
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AU - Folstein, Marshal

AU - Zhu, Jay Jiguang

AU - Mwamburi, D. Mkaya

AU - Patz, Samuel

AU - Qiu, Wei Qiao

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