The relationship between obsessive-compulsive symptoms and PARKIN genotype

The CORE-PD study

Madeleine E. Sharp, Elise Caccappolo, Helen Mejia-Santana, Ming X. Tang, Llency Rosado, Martha Orbe Reilly, Diana Ruiz, Elan D. Louis, Cynthia Comella, Martha Nance, Susan Bressman, William K Scott, Caroline Tanner, Cheryl Waters, Stanley Fahn, Lucien Cote, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. Friedman & 12 others Ronald Pfeiffer, Haydeh Payami, Eric Molho, Stuart A. Factor, John Nutt, Carmen Serrano, Maritza Arroyo, Michael W. Pauciulo, William C. Nichols, Lorraine N. Clark, Roy N. Alcalay, Karen S. Marder

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). Methods: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P=0.03; two-mutation: 24.1, P=0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P=0.05; two mutations, P=0.13). Conclusions: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype.

Original languageEnglish (US)
Pages (from-to)278-283
Number of pages6
JournalMovement Disorders
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Genotype
Mutation
Asymptomatic Diseases
Obsessive Behavior
Substantia Nigra
Heterozygote
Point Mutation
Psychiatry
Dopamine
Appointments and Schedules
Morbidity
Phenotype
Equipment and Supplies

Keywords

  • Neuropsychological
  • Obsessive-compulsive
  • Parkin
  • Parkinson's

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Sharp, M. E., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Orbe Reilly, M., ... Marder, K. S. (2015). The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study. Movement Disorders, 30(2), 278-283. https://doi.org/10.1002/mds.26065

The relationship between obsessive-compulsive symptoms and PARKIN genotype : The CORE-PD study. / Sharp, Madeleine E.; Caccappolo, Elise; Mejia-Santana, Helen; Tang, Ming X.; Rosado, Llency; Orbe Reilly, Martha; Ruiz, Diana; Louis, Elan D.; Comella, Cynthia; Nance, Martha; Bressman, Susan; Scott, William K; Tanner, Caroline; Waters, Cheryl; Fahn, Stanley; Cote, Lucien; Ford, Blair; Rezak, Michael; Novak, Kevin; Friedman, Joseph H.; Pfeiffer, Ronald; Payami, Haydeh; Molho, Eric; Factor, Stuart A.; Nutt, John; Serrano, Carmen; Arroyo, Maritza; Pauciulo, Michael W.; Nichols, William C.; Clark, Lorraine N.; Alcalay, Roy N.; Marder, Karen S.

In: Movement Disorders, Vol. 30, No. 2, 01.02.2015, p. 278-283.

Research output: Contribution to journalArticle

Sharp, ME, Caccappolo, E, Mejia-Santana, H, Tang, MX, Rosado, L, Orbe Reilly, M, Ruiz, D, Louis, ED, Comella, C, Nance, M, Bressman, S, Scott, WK, Tanner, C, Waters, C, Fahn, S, Cote, L, Ford, B, Rezak, M, Novak, K, Friedman, JH, Pfeiffer, R, Payami, H, Molho, E, Factor, SA, Nutt, J, Serrano, C, Arroyo, M, Pauciulo, MW, Nichols, WC, Clark, LN, Alcalay, RN & Marder, KS 2015, 'The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study', Movement Disorders, vol. 30, no. 2, pp. 278-283. https://doi.org/10.1002/mds.26065
Sharp ME, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Orbe Reilly M et al. The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study. Movement Disorders. 2015 Feb 1;30(2):278-283. https://doi.org/10.1002/mds.26065
Sharp, Madeleine E. ; Caccappolo, Elise ; Mejia-Santana, Helen ; Tang, Ming X. ; Rosado, Llency ; Orbe Reilly, Martha ; Ruiz, Diana ; Louis, Elan D. ; Comella, Cynthia ; Nance, Martha ; Bressman, Susan ; Scott, William K ; Tanner, Caroline ; Waters, Cheryl ; Fahn, Stanley ; Cote, Lucien ; Ford, Blair ; Rezak, Michael ; Novak, Kevin ; Friedman, Joseph H. ; Pfeiffer, Ronald ; Payami, Haydeh ; Molho, Eric ; Factor, Stuart A. ; Nutt, John ; Serrano, Carmen ; Arroyo, Maritza ; Pauciulo, Michael W. ; Nichols, William C. ; Clark, Lorraine N. ; Alcalay, Roy N. ; Marder, Karen S. / The relationship between obsessive-compulsive symptoms and PARKIN genotype : The CORE-PD study. In: Movement Disorders. 2015 ; Vol. 30, No. 2. pp. 278-283.
@article{c6aa021eda49465aa39ec289e85a29c9,
title = "The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study",
abstract = "Background: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). Methods: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P=0.03; two-mutation: 24.1, P=0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P=0.05; two mutations, P=0.13). Conclusions: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype.",
keywords = "Neuropsychological, Obsessive-compulsive, Parkin, Parkinson's",
author = "Sharp, {Madeleine E.} and Elise Caccappolo and Helen Mejia-Santana and Tang, {Ming X.} and Llency Rosado and {Orbe Reilly}, Martha and Diana Ruiz and Louis, {Elan D.} and Cynthia Comella and Martha Nance and Susan Bressman and Scott, {William K} and Caroline Tanner and Cheryl Waters and Stanley Fahn and Lucien Cote and Blair Ford and Michael Rezak and Kevin Novak and Friedman, {Joseph H.} and Ronald Pfeiffer and Haydeh Payami and Eric Molho and Factor, {Stuart A.} and John Nutt and Carmen Serrano and Maritza Arroyo and Pauciulo, {Michael W.} and Nichols, {William C.} and Clark, {Lorraine N.} and Alcalay, {Roy N.} and Marder, {Karen S.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1002/mds.26065",
language = "English (US)",
volume = "30",
pages = "278--283",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - The relationship between obsessive-compulsive symptoms and PARKIN genotype

T2 - The CORE-PD study

AU - Sharp, Madeleine E.

AU - Caccappolo, Elise

AU - Mejia-Santana, Helen

AU - Tang, Ming X.

AU - Rosado, Llency

AU - Orbe Reilly, Martha

AU - Ruiz, Diana

AU - Louis, Elan D.

AU - Comella, Cynthia

AU - Nance, Martha

AU - Bressman, Susan

AU - Scott, William K

AU - Tanner, Caroline

AU - Waters, Cheryl

AU - Fahn, Stanley

AU - Cote, Lucien

AU - Ford, Blair

AU - Rezak, Michael

AU - Novak, Kevin

AU - Friedman, Joseph H.

AU - Pfeiffer, Ronald

AU - Payami, Haydeh

AU - Molho, Eric

AU - Factor, Stuart A.

AU - Nutt, John

AU - Serrano, Carmen

AU - Arroyo, Maritza

AU - Pauciulo, Michael W.

AU - Nichols, William C.

AU - Clark, Lorraine N.

AU - Alcalay, Roy N.

AU - Marder, Karen S.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). Methods: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P=0.03; two-mutation: 24.1, P=0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P=0.05; two mutations, P=0.13). Conclusions: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype.

AB - Background: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). Methods: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P=0.03; two-mutation: 24.1, P=0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P=0.05; two mutations, P=0.13). Conclusions: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype.

KW - Neuropsychological

KW - Obsessive-compulsive

KW - Parkin

KW - Parkinson's

UR - http://www.scopus.com/inward/record.url?scp=84961320728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961320728&partnerID=8YFLogxK

U2 - 10.1002/mds.26065

DO - 10.1002/mds.26065

M3 - Article

VL - 30

SP - 278

EP - 283

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 2

ER -