The Relation between Estrogen Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer

Marc E. Lippman, Joseph C. Allegra, E. Brad Thompson, Richard Simon, Audrey Barlock, Linda Green, Karen K. Huff, Hoan my T. do, Susan C. Aitken, Robert Warren

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239 Scopus citations

Abstract

In a retrospective study we determined the relation between estrogen receptors and the response rate to cytotoxic chemotherapy in 70 patients with metastatic breast cancer. Thirty-four of 45 patients with low or absent estrogen-receptor values (<10 fmol per milligram of cytoplasmic protein) had objective responses to chemotherapy, whereas only three of 25 patients with higher values (>10 fmol per milligram of cytoplasmic protein) responded (P<0.0001). There were no statistically significant differences between the two groups in age, menopausal status, disease-free interval, Karnofsky index or prior therapy. Differences in sites of involvement or type of chemotherapy did not account for the increased response rate in receptor-negative patients. We conclude that estrogen-receptor values are an important predictor of response to cytotoxic chemotherapy in metastatic breast cancer.

Original languageEnglish (US)
Pages (from-to)1223-1228
Number of pages6
JournalNew England Journal of Medicine
Volume298
Issue number22
DOIs
StatePublished - Jun 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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    Lippman, M. E., Allegra, J. C., Thompson, E. B., Simon, R., Barlock, A., Green, L., Huff, K. K., do, H. M. T., Aitken, S. C., & Warren, R. (1978). The Relation between Estrogen Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer. New England Journal of Medicine, 298(22), 1223-1228. https://doi.org/10.1056/NEJM197806012982203