The relation between depression and parkin genotype: The CORE-PD study

A. Srivastava, M. X. Tang, H. Mejia-Santana, L. Rosado, E. D. Louis, E. Caccappolo, C. Comella, A. Colcher, A. Siderowf, D. Jennings, M. Nance, S. Bressman, William K Scott, C. Tanner, S. Mickel, H. Andrews, C. Waters, S. Fahn, L. Cote, S. FruchtB. Ford, R. N. Alcalay, B. Ross, M. Orbe Reilly, M. Rezak, K. Novak, J. H. Friedman, R. D. Pfeiffer, L. Marsh, B. Hiner, D. Merle, R. Ottman, L. N. Clark, K. Marder

Research output: Contribution to journalArticle

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Abstract

Background: Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. Methods: We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals including 88 probands with early onset PD (41 with parkin mutations, 47 without) and 240 first and second-degree relatives without PD. Results: Genotype was not associated with depression risk among probands. Among unaffected relatives of EOPD cases, only compound heterozygotes (n = 4), and not heterozygotes, had significantly increased risk of depressed mood (OR = 14.1; 95% CI 1.2-163.4), moderate to severe depression (OR = 17.8; 95% CI 1.0-332.0), depression (score ≥ 15) on the Beck Depression Inventory II (BDI-II) (OR = 51.9; 95% CI 4.1-657.4), and BDI-II total depression score (β = 8.4; 95% CI 2.4-11.3) compared to those without parkin mutations. Conclusions: Relatives of EOPD cases with compound heterozygous mutations and without diagnosed PD may have a higher risk of depression compared to relatives without parkin mutations. These findings support evidence of a genetic contribution to depression and may extend the phenotypic spectrum of parkin mutations to include non-motor manifestations that precede the development of PD.

Original languageEnglish
Pages (from-to)740-744
Number of pages5
JournalParkinsonism and Related Disorders
Volume17
Issue number10
DOIs
StatePublished - Dec 1 2011

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Genotype
Depression
Mutation
Parkinson Disease
Heterozygote
Equipment and Supplies
Psychiatry
Health

Keywords

  • Depression
  • Early onset Parkinson's disease
  • Genetics
  • Neuropsychiatry
  • Parkin
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Srivastava, A., Tang, M. X., Mejia-Santana, H., Rosado, L., Louis, E. D., Caccappolo, E., ... Marder, K. (2011). The relation between depression and parkin genotype: The CORE-PD study. Parkinsonism and Related Disorders, 17(10), 740-744. https://doi.org/10.1016/j.parkreldis.2011.07.008

The relation between depression and parkin genotype : The CORE-PD study. / Srivastava, A.; Tang, M. X.; Mejia-Santana, H.; Rosado, L.; Louis, E. D.; Caccappolo, E.; Comella, C.; Colcher, A.; Siderowf, A.; Jennings, D.; Nance, M.; Bressman, S.; Scott, William K; Tanner, C.; Mickel, S.; Andrews, H.; Waters, C.; Fahn, S.; Cote, L.; Frucht, S.; Ford, B.; Alcalay, R. N.; Ross, B.; Orbe Reilly, M.; Rezak, M.; Novak, K.; Friedman, J. H.; Pfeiffer, R. D.; Marsh, L.; Hiner, B.; Merle, D.; Ottman, R.; Clark, L. N.; Marder, K.

In: Parkinsonism and Related Disorders, Vol. 17, No. 10, 01.12.2011, p. 740-744.

Research output: Contribution to journalArticle

Srivastava, A, Tang, MX, Mejia-Santana, H, Rosado, L, Louis, ED, Caccappolo, E, Comella, C, Colcher, A, Siderowf, A, Jennings, D, Nance, M, Bressman, S, Scott, WK, Tanner, C, Mickel, S, Andrews, H, Waters, C, Fahn, S, Cote, L, Frucht, S, Ford, B, Alcalay, RN, Ross, B, Orbe Reilly, M, Rezak, M, Novak, K, Friedman, JH, Pfeiffer, RD, Marsh, L, Hiner, B, Merle, D, Ottman, R, Clark, LN & Marder, K 2011, 'The relation between depression and parkin genotype: The CORE-PD study', Parkinsonism and Related Disorders, vol. 17, no. 10, pp. 740-744. https://doi.org/10.1016/j.parkreldis.2011.07.008
Srivastava A, Tang MX, Mejia-Santana H, Rosado L, Louis ED, Caccappolo E et al. The relation between depression and parkin genotype: The CORE-PD study. Parkinsonism and Related Disorders. 2011 Dec 1;17(10):740-744. https://doi.org/10.1016/j.parkreldis.2011.07.008
Srivastava, A. ; Tang, M. X. ; Mejia-Santana, H. ; Rosado, L. ; Louis, E. D. ; Caccappolo, E. ; Comella, C. ; Colcher, A. ; Siderowf, A. ; Jennings, D. ; Nance, M. ; Bressman, S. ; Scott, William K ; Tanner, C. ; Mickel, S. ; Andrews, H. ; Waters, C. ; Fahn, S. ; Cote, L. ; Frucht, S. ; Ford, B. ; Alcalay, R. N. ; Ross, B. ; Orbe Reilly, M. ; Rezak, M. ; Novak, K. ; Friedman, J. H. ; Pfeiffer, R. D. ; Marsh, L. ; Hiner, B. ; Merle, D. ; Ottman, R. ; Clark, L. N. ; Marder, K. / The relation between depression and parkin genotype : The CORE-PD study. In: Parkinsonism and Related Disorders. 2011 ; Vol. 17, No. 10. pp. 740-744.
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abstract = "Background: Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. Methods: We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals including 88 probands with early onset PD (41 with parkin mutations, 47 without) and 240 first and second-degree relatives without PD. Results: Genotype was not associated with depression risk among probands. Among unaffected relatives of EOPD cases, only compound heterozygotes (n = 4), and not heterozygotes, had significantly increased risk of depressed mood (OR = 14.1; 95{\%} CI 1.2-163.4), moderate to severe depression (OR = 17.8; 95{\%} CI 1.0-332.0), depression (score ≥ 15) on the Beck Depression Inventory II (BDI-II) (OR = 51.9; 95{\%} CI 4.1-657.4), and BDI-II total depression score (β = 8.4; 95{\%} CI 2.4-11.3) compared to those without parkin mutations. Conclusions: Relatives of EOPD cases with compound heterozygous mutations and without diagnosed PD may have a higher risk of depression compared to relatives without parkin mutations. These findings support evidence of a genetic contribution to depression and may extend the phenotypic spectrum of parkin mutations to include non-motor manifestations that precede the development of PD.",
keywords = "Depression, Early onset Parkinson's disease, Genetics, Neuropsychiatry, Parkin, Parkinson's disease",
author = "A. Srivastava and Tang, {M. X.} and H. Mejia-Santana and L. Rosado and Louis, {E. D.} and E. Caccappolo and C. Comella and A. Colcher and A. Siderowf and D. Jennings and M. Nance and S. Bressman and Scott, {William K} and C. Tanner and S. Mickel and H. Andrews and C. Waters and S. Fahn and L. Cote and S. Frucht and B. Ford and Alcalay, {R. N.} and B. Ross and {Orbe Reilly}, M. and M. Rezak and K. Novak and Friedman, {J. H.} and Pfeiffer, {R. D.} and L. Marsh and B. Hiner and D. Merle and R. Ottman and Clark, {L. N.} and K. Marder",
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T1 - The relation between depression and parkin genotype

T2 - The CORE-PD study

AU - Srivastava, A.

AU - Tang, M. X.

AU - Mejia-Santana, H.

AU - Rosado, L.

AU - Louis, E. D.

AU - Caccappolo, E.

AU - Comella, C.

AU - Colcher, A.

AU - Siderowf, A.

AU - Jennings, D.

AU - Nance, M.

AU - Bressman, S.

AU - Scott, William K

AU - Tanner, C.

AU - Mickel, S.

AU - Andrews, H.

AU - Waters, C.

AU - Fahn, S.

AU - Cote, L.

AU - Frucht, S.

AU - Ford, B.

AU - Alcalay, R. N.

AU - Ross, B.

AU - Orbe Reilly, M.

AU - Rezak, M.

AU - Novak, K.

AU - Friedman, J. H.

AU - Pfeiffer, R. D.

AU - Marsh, L.

AU - Hiner, B.

AU - Merle, D.

AU - Ottman, R.

AU - Clark, L. N.

AU - Marder, K.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. Methods: We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals including 88 probands with early onset PD (41 with parkin mutations, 47 without) and 240 first and second-degree relatives without PD. Results: Genotype was not associated with depression risk among probands. Among unaffected relatives of EOPD cases, only compound heterozygotes (n = 4), and not heterozygotes, had significantly increased risk of depressed mood (OR = 14.1; 95% CI 1.2-163.4), moderate to severe depression (OR = 17.8; 95% CI 1.0-332.0), depression (score ≥ 15) on the Beck Depression Inventory II (BDI-II) (OR = 51.9; 95% CI 4.1-657.4), and BDI-II total depression score (β = 8.4; 95% CI 2.4-11.3) compared to those without parkin mutations. Conclusions: Relatives of EOPD cases with compound heterozygous mutations and without diagnosed PD may have a higher risk of depression compared to relatives without parkin mutations. These findings support evidence of a genetic contribution to depression and may extend the phenotypic spectrum of parkin mutations to include non-motor manifestations that precede the development of PD.

AB - Background: Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. Methods: We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals including 88 probands with early onset PD (41 with parkin mutations, 47 without) and 240 first and second-degree relatives without PD. Results: Genotype was not associated with depression risk among probands. Among unaffected relatives of EOPD cases, only compound heterozygotes (n = 4), and not heterozygotes, had significantly increased risk of depressed mood (OR = 14.1; 95% CI 1.2-163.4), moderate to severe depression (OR = 17.8; 95% CI 1.0-332.0), depression (score ≥ 15) on the Beck Depression Inventory II (BDI-II) (OR = 51.9; 95% CI 4.1-657.4), and BDI-II total depression score (β = 8.4; 95% CI 2.4-11.3) compared to those without parkin mutations. Conclusions: Relatives of EOPD cases with compound heterozygous mutations and without diagnosed PD may have a higher risk of depression compared to relatives without parkin mutations. These findings support evidence of a genetic contribution to depression and may extend the phenotypic spectrum of parkin mutations to include non-motor manifestations that precede the development of PD.

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KW - Early onset Parkinson's disease

KW - Genetics

KW - Neuropsychiatry

KW - Parkin

KW - Parkinson's disease

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