The relapse of hairy cell leukemia after a 32‐year remission

J. Donald Temple; William J. Harrington; Clyde B. McCoy

doi:10.1002/1097-0142(19910401)67:7<1943::AID-CNCR2820670719>3.0.CO;2-J

The relapse of hairy cell leukemia after a 32‐year remission

J. Donald Temple, William J. Harrington, Clyde B. McCoy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The optimum therapy for hairy cell leukemia (HCL) is controversial. Dramatic responses to interferon-alpha and 2'-deoxycoformycin overshadow the established role of splenectomy in HCL, and patients currently can avoid surgery altogether. A case is presented of clinical remission lasting 32 years after splenectomy-a prolonged normal life, without medication or medical intervention. When relapse occurred, the patient's response to interferon-alpha was prompt and predictable. Prognostic variables are an important consideration at the time of diagnosis in predicting the response to splenectomy.

Original language	English (US)
Pages (from-to)	1943-1945
Number of pages	3
Journal	Cancer
Volume	67
Issue number	7
DOIs	https://doi.org/10.1002/1097-0142(19910401)67:7<1943::AID-CNCR2820670719>3.0.CO;2-J
State	Published - Apr 1 1991

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "The optimum therapy for hairy cell leukemia (HCL) is controversial. Dramatic responses to interferon-alpha and 2'-deoxycoformycin overshadow the established role of splenectomy in HCL, and patients currently can avoid surgery altogether. A case is presented of clinical remission lasting 32 years after splenectomy-a prolonged normal life, without medication or medical intervention. When relapse occurred, the patient's response to interferon-alpha was prompt and predictable. Prognostic variables are an important consideration at the time of diagnosis in predicting the response to splenectomy.",

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AB - The optimum therapy for hairy cell leukemia (HCL) is controversial. Dramatic responses to interferon-alpha and 2'-deoxycoformycin overshadow the established role of splenectomy in HCL, and patients currently can avoid surgery altogether. A case is presented of clinical remission lasting 32 years after splenectomy-a prolonged normal life, without medication or medical intervention. When relapse occurred, the patient's response to interferon-alpha was prompt and predictable. Prognostic variables are an important consideration at the time of diagnosis in predicting the response to splenectomy.

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