The placental concentrations of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and total proteins were determined in control and oophorectomized-progesterone-treated (O/P) pregnant rabbits in order to elucidate the mechanism of the increase in placental weight observed in the O/P does. There was no significant difference in the placental DNA and protein concentrations between the control and experimental animals although the total placental DNA and protein contents were significantly higher in the latter. Both RNA concentration and total RNA were higher in the placentas from the oophorectomized group. These findings indicated that the increase in placental weight in the treated rabbits was caused by cellular hyperplasia, without demonstrable hypertrophy.
ASJC Scopus subject areas
- Obstetrics and Gynecology