The regulatory effect of estrogens on fetal growth. III. Placental deoxyribonucleic acid, ribonucleic acid, and proteins

Samir N. Beydoun; Raja W. Abdul-Karim; Mary E. Haviland

doi:10.1016/0002-9378(74)90339-1

The regulatory effect of estrogens on fetal growth. III. Placental deoxyribonucleic acid, ribonucleic acid, and proteins

Samir N. Beydoun, Raja W. Abdul-Karim, Mary E. Haviland

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The placental concentrations of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and total proteins were determined in control and oophorectomized-progesterone-treated (O/P) pregnant rabbits in order to elucidate the mechanism of the increase in placental weight observed in the O/P does. There was no significant difference in the placental DNA and protein concentrations between the control and experimental animals although the total placental DNA and protein contents were significantly higher in the latter. Both RNA concentration and total RNA were higher in the placentas from the oophorectomized group. These findings indicated that the increase in placental weight in the treated rabbits was caused by cellular hyperplasia, without demonstrable hypertrophy.

Original language	English (US)
Pages (from-to)	918-921
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	120
Issue number	7
DOIs	https://doi.org/10.1016/0002-9378(74)90339-1
State	Published - Dec 1 1974

ASJC Scopus subject areas

Obstetrics and Gynecology

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title = "The regulatory effect of estrogens on fetal growth. III. Placental deoxyribonucleic acid, ribonucleic acid, and proteins",

abstract = "The placental concentrations of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and total proteins were determined in control and oophorectomized-progesterone-treated (O/P) pregnant rabbits in order to elucidate the mechanism of the increase in placental weight observed in the O/P does. There was no significant difference in the placental DNA and protein concentrations between the control and experimental animals although the total placental DNA and protein contents were significantly higher in the latter. Both RNA concentration and total RNA were higher in the placentas from the oophorectomized group. These findings indicated that the increase in placental weight in the treated rabbits was caused by cellular hyperplasia, without demonstrable hypertrophy.",

author = "Beydoun, {Samir N.} and Abdul-Karim, {Raja W.} and Haviland, {Mary E.}",

note = "Funding Information: From the Reproductive Biology Unit, Department of Obstetrics and Gynecology, State University York, Upstate Medical Center. Supported in part by Institutionat Grant No. 11-8656 from the United States Public Health Service and by Grant No. IR03 17662-01 from the National Institute of Mental Health. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Beydoun, Samir N.

AU - Abdul-Karim, Raja W.

AU - Haviland, Mary E.

N1 - Funding Information: From the Reproductive Biology Unit, Department of Obstetrics and Gynecology, State University York, Upstate Medical Center. Supported in part by Institutionat Grant No. 11-8656 from the United States Public Health Service and by Grant No. IR03 17662-01 from the National Institute of Mental Health. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - The placental concentrations of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and total proteins were determined in control and oophorectomized-progesterone-treated (O/P) pregnant rabbits in order to elucidate the mechanism of the increase in placental weight observed in the O/P does. There was no significant difference in the placental DNA and protein concentrations between the control and experimental animals although the total placental DNA and protein contents were significantly higher in the latter. Both RNA concentration and total RNA were higher in the placentas from the oophorectomized group. These findings indicated that the increase in placental weight in the treated rabbits was caused by cellular hyperplasia, without demonstrable hypertrophy.

AB - The placental concentrations of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and total proteins were determined in control and oophorectomized-progesterone-treated (O/P) pregnant rabbits in order to elucidate the mechanism of the increase in placental weight observed in the O/P does. There was no significant difference in the placental DNA and protein concentrations between the control and experimental animals although the total placental DNA and protein contents were significantly higher in the latter. Both RNA concentration and total RNA were higher in the placentas from the oophorectomized group. These findings indicated that the increase in placental weight in the treated rabbits was caused by cellular hyperplasia, without demonstrable hypertrophy.

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The regulatory effect of estrogens on fetal growth. III. Placental deoxyribonucleic acid, ribonucleic acid, and proteins

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