As the growth state of cells is known to affect cellular cholesterol homeostasis, we tested whether alteration of cell proliferation would regulate HDL receptor binding activity. All mitogens reduced HDL binding in a dose-related manner and this was associated with increased LDL receptor activity. Conversely, growth inhibition increased HDL receptor activity. Mitogens, by down-regulating HDL receptor-mediated cholesterol efflux from cells, could contribute to cell cholesterol accumulation.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Drug Development, Supplement|
|State||Published - Jan 1 1990|
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