The regulation of HDL receptor activity in extrahepatic cells

E. L. Bierman, J. F. Oram, J. P. Slotte, A. Mendez

Research output: Contribution to journalArticlepeer-review

Abstract

As the growth state of cells is known to affect cellular cholesterol homeostasis, we tested whether alteration of cell proliferation would regulate HDL receptor binding activity. All mitogens reduced HDL binding in a dose-related manner and this was associated with increased LDL receptor activity. Conversely, growth inhibition increased HDL receptor activity. Mitogens, by down-regulating HDL receptor-mediated cholesterol efflux from cells, could contribute to cell cholesterol accumulation.

Original languageEnglish (US)
Pages (from-to)77-78
Number of pages2
JournalJournal of Drug Development, Supplement
Volume3
Issue number1
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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