A sensitive and specific radioimmunoassay for somatostatin (SRIF) has been used to determine the regional distribution of SRIF in rat brain. The hypothalamus contained the highest concentrations of SRIF. Lower, but significant amounts of SRIF, were present outside of the hypothelamus. Within the hypothalamus, the concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalamic nuclei contained some of this material. The implications of this distribution are discussed.
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