The regional distribution of somatostatin in the rat brain

M. Brownstein; A. Arimura; H. Sato; A. V. Schally; J. S. Kizerf

doi:10.1210/endo-96-6-1456

The regional distribution of somatostatin in the rat brain

M. Brownstein, A. Arimura, H. Sato, A. V. Schally, J. S. Kizerf

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Abstract

A sensitive and specific radioimmunoassay for somatostatin (SRIF) has been used to determine the regional distribution of SRIF in rat brain. The hypothalamus contained the highest concentrations of SRIF. Lower, but significant amounts of SRIF, were present outside of the hypothelamus. Within the hypothalamus, the concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalamic nuclei contained some of this material. The implications of this distribution are discussed.

Original language	English (US)
Pages (from-to)	1456-1461
Number of pages	6
Journal	Endocrinology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1210/endo-96-6-1456
State	Published - Jun 1975
Externally published	Yes

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Endocrinology

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AU - Schally, A. V.

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AB - A sensitive and specific radioimmunoassay for somatostatin (SRIF) has been used to determine the regional distribution of SRIF in rat brain. The hypothalamus contained the highest concentrations of SRIF. Lower, but significant amounts of SRIF, were present outside of the hypothelamus. Within the hypothalamus, the concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalamic nuclei contained some of this material. The implications of this distribution are discussed.

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The regional distribution of somatostatin in the rat brain

Abstract

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