The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease

Oliver Zivanovic, Yukio Sonoda, John P. Diaz, Douglas A. Levine, Carol L. Brown, Dennis S. Chi, Richard R. Barakat, Nadeem R. Abu-Rustum

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Background: The aim was to describe the rate of laparoscopic trocar-related subcutaneous tumor implants in women with underlying malignant disease. Methods: An analysis of a prospective database of all patients undergoing transperitoneal laparoscopic procedures for malignant conditions performed by the gynecologic oncology service. Results: Between July 1991 and April 2007, laparoscopic procedures were performed in 1694 patients with a malignant intraabdominal condition and in 505 breast cancer patients undergoing risk-reducing, diagnostic or therapeutic laparoscopic procedures without intraabdominal disease. Port-site metastases were documented in 20 of 1694 patients (1.18%) who underwent laparoscopic procedures for a malignant intraabdominal condition. Of these, 15 patients had a diagnosis of epithelial ovarian or fallopian tube carcinoma, 2 had breast cancer, 2 had cervical cancer, and 1 had uterine cancer. Nineteen of 20 patients (95%) had simultaneous carcinomatosis or metastases to other sites at the time of port-site metastasis. Patients who developed port-site metastases within 7 months from the laparoscopic procedure had a median survival of 12 months whereas patients who developed port-site metastasis > 7 months had a median survival of 37 months (P = 0.004). No port-site recurrence was documented in patients undergoing risk-reducing, diagnostic or therapeutic laparoscopic procedures for breast cancer without intraabdominal disease. Conclusion: The rate of port-site tumor implantation after laparoscopic procedures in women with malignant disease is low and almost always occurs in the setting of synchronous, advanced intraabdominal or distant metastatic disease. The presence of port-site implantation is a surrogate for advanced disease and should not be used as an argument against laparoscopic surgery in gynecologic malignancies.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalGynecologic Oncology
Volume111
Issue number3
DOIs
StatePublished - Dec 1 2008

Fingerprint

Neoplasm Metastasis
Breast Neoplasms
Carcinoma
Neoplasms
Uterine Neoplasms
Survival
Fallopian Tubes
Surgical Instruments
Uterine Cervical Neoplasms
Laparoscopy
Databases
Recurrence
Therapeutics

Keywords

  • Gynecologic malignancies
  • Laparoscopy
  • Port-site metastases
  • Trocar
  • Tumor implantation

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Zivanovic, O., Sonoda, Y., Diaz, J. P., Levine, D. A., Brown, C. L., Chi, D. S., ... Abu-Rustum, N. R. (2008). The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease. Gynecologic Oncology, 111(3), 431-437. https://doi.org/10.1016/j.ygyno.2008.08.024

The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease. / Zivanovic, Oliver; Sonoda, Yukio; Diaz, John P.; Levine, Douglas A.; Brown, Carol L.; Chi, Dennis S.; Barakat, Richard R.; Abu-Rustum, Nadeem R.

In: Gynecologic Oncology, Vol. 111, No. 3, 01.12.2008, p. 431-437.

Research output: Contribution to journalArticle

Zivanovic, O, Sonoda, Y, Diaz, JP, Levine, DA, Brown, CL, Chi, DS, Barakat, RR & Abu-Rustum, NR 2008, 'The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease', Gynecologic Oncology, vol. 111, no. 3, pp. 431-437. https://doi.org/10.1016/j.ygyno.2008.08.024
Zivanovic, Oliver ; Sonoda, Yukio ; Diaz, John P. ; Levine, Douglas A. ; Brown, Carol L. ; Chi, Dennis S. ; Barakat, Richard R. ; Abu-Rustum, Nadeem R. / The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease. In: Gynecologic Oncology. 2008 ; Vol. 111, No. 3. pp. 431-437.
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AU - Brown, Carol L.

AU - Chi, Dennis S.

AU - Barakat, Richard R.

AU - Abu-Rustum, Nadeem R.

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