The rat model of endocarditis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The rat model of endocarditis is a well established experimental protocol which closely approximates human native valve endocarditis. The rat model of endocarditis has been used to examine the role of particular streptococcal virulence factors, to assess immunoprotective strategies, and to evaluate the efficacy of selected antibiotic treatment regimens for streptococcal endocarditis. Like humans, rats are generally susceptible to endocarditis only if the cardiac valves have been damaged. In the rat model of endocarditis, damage to the aortic valve and sterile vegetation formation is accomplished by insertion of a polyethylene catheter through the carotid artery into the left ventricle. Following catheter insertion, an inoculum of streptococci are injected intravenously. Vegetations removed from the heart valves during thoracotomy of euthanized animals are qualitatively cultured for streptococcal infection. The method, including investigator safety considerations, is described in detail.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalMethods in Cell Science
Volume20
Issue number1-4
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Endocarditis
Rats
Catheters
Heart Valves
Polyethylene
Virulence Factors
Antibiotics
Polyethylenes
Streptococcal Infections
Animals
Thoracotomy
Anti-Bacterial Agents
Streptococcus
Aortic Valve
Carotid Arteries
Heart Ventricles
Research Personnel
Safety

Keywords

  • Endocarditis
  • Rat
  • Streptococci

ASJC Scopus subject areas

  • Cell Biology

Cite this

The rat model of endocarditis. / Munro, Cindy.

In: Methods in Cell Science, Vol. 20, No. 1-4, 01.12.1998, p. 203-207.

Research output: Contribution to journalArticle

Munro, Cindy. / The rat model of endocarditis. In: Methods in Cell Science. 1998 ; Vol. 20, No. 1-4. pp. 203-207.
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