The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy

W. G. Bradley, Dorothy Murchison, M. J. Day

Research output: Contribution to journalArticle

13 Scopus citations


In this study attention was given to the possibility that axoplasmic flow occurs not at two preferential velocities (the fast and the slow), but at many rates. A method of analysing this possibility was developed. In a study of axoplasmic flow in mice of the 'wobbler' strain and their littermate controls evidence was obtained for the existence of many different rates of flow, the amount per unit velocity interval decreasing with increasing velocity. No difference could be detected between diseased and normal animals. The many technical problems inherent in such a study, and the implications of these results are discussed.

Original languageEnglish (US)
Pages (from-to)185-197
Number of pages13
JournalBrain Research
Issue number1
StatePublished - Dec 10 1971
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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