The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy

Walter G Bradley, Dorothy Murchison, M. J. Day

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In this study attention was given to the possibility that axoplasmic flow occurs not at two preferential velocities (the fast and the slow), but at many rates. A method of analysing this possibility was developed. In a study of axoplasmic flow in mice of the 'wobbler' strain and their littermate controls evidence was obtained for the existence of many different rates of flow, the amount per unit velocity interval decreasing with increasing velocity. No difference could be detected between diseased and normal animals. The many technical problems inherent in such a study, and the implications of these results are discussed.

Original languageEnglish
Pages (from-to)185-197
Number of pages13
JournalBrain Research
Volume35
Issue number1
DOIs
StatePublished - Dec 10 1971
Externally publishedYes

Fingerprint

Spinal Muscular Atrophy
Axonal Transport
Animal Diseases

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy. / Bradley, Walter G; Murchison, Dorothy; Day, M. J.

In: Brain Research, Vol. 35, No. 1, 10.12.1971, p. 185-197.

Research output: Contribution to journalArticle

@article{ff477e94f28c4f0a800156353a841399,
title = "The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy",
abstract = "In this study attention was given to the possibility that axoplasmic flow occurs not at two preferential velocities (the fast and the slow), but at many rates. A method of analysing this possibility was developed. In a study of axoplasmic flow in mice of the 'wobbler' strain and their littermate controls evidence was obtained for the existence of many different rates of flow, the amount per unit velocity interval decreasing with increasing velocity. No difference could be detected between diseased and normal animals. The many technical problems inherent in such a study, and the implications of these results are discussed.",
author = "Bradley, {Walter G} and Dorothy Murchison and Day, {M. J.}",
year = "1971",
month = "12",
day = "10",
doi = "10.1016/0006-8993(71)90604-4",
language = "English",
volume = "35",
pages = "185--197",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy

AU - Bradley, Walter G

AU - Murchison, Dorothy

AU - Day, M. J.

PY - 1971/12/10

Y1 - 1971/12/10

N2 - In this study attention was given to the possibility that axoplasmic flow occurs not at two preferential velocities (the fast and the slow), but at many rates. A method of analysing this possibility was developed. In a study of axoplasmic flow in mice of the 'wobbler' strain and their littermate controls evidence was obtained for the existence of many different rates of flow, the amount per unit velocity interval decreasing with increasing velocity. No difference could be detected between diseased and normal animals. The many technical problems inherent in such a study, and the implications of these results are discussed.

AB - In this study attention was given to the possibility that axoplasmic flow occurs not at two preferential velocities (the fast and the slow), but at many rates. A method of analysing this possibility was developed. In a study of axoplasmic flow in mice of the 'wobbler' strain and their littermate controls evidence was obtained for the existence of many different rates of flow, the amount per unit velocity interval decreasing with increasing velocity. No difference could be detected between diseased and normal animals. The many technical problems inherent in such a study, and the implications of these results are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0015219035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015219035&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(71)90604-4

DO - 10.1016/0006-8993(71)90604-4

M3 - Article

VL - 35

SP - 185

EP - 197

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -