The radiation therapy of early stage cutaneous T-cell lymphoma

Bizhan Micaily, Charles Moser, Eric C. Vonderheid, Christopher Koprowski, David Lightfoot, Arnold Markoe, Luther Brady

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Results of different radiotherapy schedules used for early stage (T1-2, N0-1, M0) cutaneous T-cell lymphoma (CTCL) are compared in a series of 45 patients (22 patients treated with high dose total skin electron beam therapy (TSEB) with curative intent, 18 patients treated with palliative radiotherapy, and 5 patients treated with high dose local electron beam). At 3, 5, and 10 years after diagnosis the high dose TSEB treatment group had a probability of overall survival of 91%, 86%, and 75%, respectively, compared with 94%, 88%, and 88% for the palliative treatment group. The complete response (CR) rate for the high dose TSEB treatment group was 82% ( 18 22), compared with a 57% ( 4 7) complete response rate for seven patients in the palliative group who received low dose TSEB (<25 Gy in 6-7 weeks) followed by daily application of topical mechlorethamine hydrochloride (HN2). However, the probability of continued remission at 3, 5, and 10 years was 44%, 44%, and 33%, respectively, for the high dose TSEB group and 25%, 25%, and 0%, respectively, for the low dose TSEB + HN2 group. The median disease-free survival was 17.5 months for the high dose TSEB group versus 5.5 months for the low dose TSEB + HN2 group. The five patients who were treated with high doses of local electrons to a single local field had an overall survival rate of 80%, a median survival rate of 64 months, and a median length of continued remission of 31 months. These results indicate that high-dose electron beam can result in long-term disease-free survival in patients with localized and limited extent skin involvement with cutaneous T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1333-1339
Number of pages7
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume18
Issue number6
DOIs
StatePublished - Jun 1990
Externally publishedYes

Keywords

  • Complete response
  • Cutaneous T-cell lymphoma
  • Mechlorethamine hydrochloride
  • Total skin electron beam radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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