The question of PANDAS in adults

Sara M. Bodner, Syed A. Morshed, Bradley S. Peterson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Background: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a well-defined cause of obsessive-compulsive disorder in children. However, they have not been described or fully investigated in adults newly diagnosed with obsessive-compulsive disorder. Methods: We describe an adult with onset of obsessive-compulsive disorder at 25 years of age after a severe antibiotic-responsive pharyngitis. He was evaluated with multiple psychiatric rating scales for obsessive-compulsive disorder and Tourette's syndrome, as well as with serologic assays and radiologic studies. Results: In all respects except age our patient fulfilled established criteria for PANDAS. Assays for antibodies to group A β-hematolytic streptococci, serum D8,17 lymphocytes, antistriatal (neuronal) antibodies, and anticytoskeletal antibodies all supported the hypothesis that a poststreptococcal process was active. Magnetic resonance imaging was abnormal and is described. Conclusions: The findings suggest that this patient's illness is similar to PANDAS in presentation and that poststreptococcal disease may result in adult-onset obsessive-compulsive disorder.

Original languageEnglish (US)
Pages (from-to)807-810
Number of pages4
JournalBiological Psychiatry
Volume49
Issue number9
DOIs
StatePublished - May 1 2001

Keywords

  • Attention-deficit/hyperactivity disorder
  • Obsessive-compulsive disorder
  • PANDAS
  • Poststreptococcal disease
  • Poststreptococcal neurologic disorder
  • Tics

ASJC Scopus subject areas

  • Biological Psychiatry

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    Bodner, S. M., Morshed, S. A., & Peterson, B. S. (2001). The question of PANDAS in adults. Biological Psychiatry, 49(9), 807-810. https://doi.org/10.1016/S0006-3223(00)01127-6