The quantitative lung index (QLI): A gestational ageindependent sonographic predictor of fetal lung growth

Rubén A. Quintero, Luis F. Quintero, Ramen Chmait, Libardo Gómez Castro, Lisa M. Korst, Moshe Fridman, Eftichia V. Kontopoulos

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Objective: We sought to develop a gestational ageindependent sonographic parameter to characterize lung growth. Study Design: Reported descriptors of lung growth, including lung-to-head circumference (HC) ratio (LHR) and observed/expected LHR, were examined. A new index, the quantitative lung index (QLI) was derived using published data on HC and the area of the base of the right lung. Results: Neither the LHR nor the observed/expected LHR proved to be gestational age independent. Right lung growth can be expressed using the following formula: QLI = lung area/(HC/10)2. The 50th percentile of the QLI remained constant at approximately 1.0 for the gestational age between 16-32 weeks. A small lung (<1st percentile) was defined as a QLI <0.6. Conclusion: Fetal right lung growth can be adequately described using the QLI, independent of gestational age. Further studies are needed to assess the clinical accuracy of the QLI in characterizing fetal right lung growth.

Original languageEnglish (US)
Pages (from-to)544.e1-544.e8
JournalAmerican journal of obstetrics and gynecology
Volume205
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • congenital diaphragmatic hernia
  • lung-to-head circumference ratio
  • tracheal occlusion

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Quintero, R. A., Quintero, L. F., Chmait, R., Gómez Castro, L., Korst, L. M., Fridman, M., & Kontopoulos, E. V. (2011). The quantitative lung index (QLI): A gestational ageindependent sonographic predictor of fetal lung growth. American journal of obstetrics and gynecology, 205(6), 544.e1-544.e8. https://doi.org/10.1016/j.ajog.2011.07.031