The quantitative lung index (QLI): A gestational ageindependent sonographic predictor of fetal lung growth

Rubén A. Quintero, Luis F. Quintero, Ramen Chmait, Libardo Gómez Castro, Lisa M. Korst, Moshe Fridman, Eftichia V. Kontopoulos

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: We sought to develop a gestational ageindependent sonographic parameter to characterize lung growth. Study Design: Reported descriptors of lung growth, including lung-to-head circumference (HC) ratio (LHR) and observed/expected LHR, were examined. A new index, the quantitative lung index (QLI) was derived using published data on HC and the area of the base of the right lung. Results: Neither the LHR nor the observed/expected LHR proved to be gestational age independent. Right lung growth can be expressed using the following formula: QLI = lung area/(HC/10)2. The 50th percentile of the QLI remained constant at approximately 1.0 for the gestational age between 16-32 weeks. A small lung (<1st percentile) was defined as a QLI <0.6. Conclusion: Fetal right lung growth can be adequately described using the QLI, independent of gestational age. Further studies are needed to assess the clinical accuracy of the QLI in characterizing fetal right lung growth.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number6
DOIs
StatePublished - Dec 1 2011

Fingerprint

Fetal Development
Lung
Gestational Age
Growth
Head

Keywords

  • congenital diaphragmatic hernia
  • lung-to-head circumference ratio
  • tracheal occlusion

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Quintero, R. A., Quintero, L. F., Chmait, R., Gómez Castro, L., Korst, L. M., Fridman, M., & Kontopoulos, E. V. (2011). The quantitative lung index (QLI): A gestational ageindependent sonographic predictor of fetal lung growth. American Journal of Obstetrics and Gynecology, 205(6). https://doi.org/10.1016/j.ajog.2011.07.031

The quantitative lung index (QLI) : A gestational ageindependent sonographic predictor of fetal lung growth. / Quintero, Rubén A.; Quintero, Luis F.; Chmait, Ramen; Gómez Castro, Libardo; Korst, Lisa M.; Fridman, Moshe; Kontopoulos, Eftichia V.

In: American Journal of Obstetrics and Gynecology, Vol. 205, No. 6, 01.12.2011.

Research output: Contribution to journalArticle

Quintero, Rubén A. ; Quintero, Luis F. ; Chmait, Ramen ; Gómez Castro, Libardo ; Korst, Lisa M. ; Fridman, Moshe ; Kontopoulos, Eftichia V. / The quantitative lung index (QLI) : A gestational ageindependent sonographic predictor of fetal lung growth. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 205, No. 6.
@article{c6b13edb609b4c24a5e41a8b344282fe,
title = "The quantitative lung index (QLI): A gestational ageindependent sonographic predictor of fetal lung growth",
abstract = "Objective: We sought to develop a gestational ageindependent sonographic parameter to characterize lung growth. Study Design: Reported descriptors of lung growth, including lung-to-head circumference (HC) ratio (LHR) and observed/expected LHR, were examined. A new index, the quantitative lung index (QLI) was derived using published data on HC and the area of the base of the right lung. Results: Neither the LHR nor the observed/expected LHR proved to be gestational age independent. Right lung growth can be expressed using the following formula: QLI = lung area/(HC/10)2. The 50th percentile of the QLI remained constant at approximately 1.0 for the gestational age between 16-32 weeks. A small lung (<1st percentile) was defined as a QLI <0.6. Conclusion: Fetal right lung growth can be adequately described using the QLI, independent of gestational age. Further studies are needed to assess the clinical accuracy of the QLI in characterizing fetal right lung growth.",
keywords = "congenital diaphragmatic hernia, lung-to-head circumference ratio, tracheal occlusion",
author = "Quintero, {Rub{\'e}n A.} and Quintero, {Luis F.} and Ramen Chmait and {G{\'o}mez Castro}, Libardo and Korst, {Lisa M.} and Moshe Fridman and Kontopoulos, {Eftichia V.}",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.ajog.2011.07.031",
language = "English",
volume = "205",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - The quantitative lung index (QLI)

T2 - A gestational ageindependent sonographic predictor of fetal lung growth

AU - Quintero, Rubén A.

AU - Quintero, Luis F.

AU - Chmait, Ramen

AU - Gómez Castro, Libardo

AU - Korst, Lisa M.

AU - Fridman, Moshe

AU - Kontopoulos, Eftichia V.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objective: We sought to develop a gestational ageindependent sonographic parameter to characterize lung growth. Study Design: Reported descriptors of lung growth, including lung-to-head circumference (HC) ratio (LHR) and observed/expected LHR, were examined. A new index, the quantitative lung index (QLI) was derived using published data on HC and the area of the base of the right lung. Results: Neither the LHR nor the observed/expected LHR proved to be gestational age independent. Right lung growth can be expressed using the following formula: QLI = lung area/(HC/10)2. The 50th percentile of the QLI remained constant at approximately 1.0 for the gestational age between 16-32 weeks. A small lung (<1st percentile) was defined as a QLI <0.6. Conclusion: Fetal right lung growth can be adequately described using the QLI, independent of gestational age. Further studies are needed to assess the clinical accuracy of the QLI in characterizing fetal right lung growth.

AB - Objective: We sought to develop a gestational ageindependent sonographic parameter to characterize lung growth. Study Design: Reported descriptors of lung growth, including lung-to-head circumference (HC) ratio (LHR) and observed/expected LHR, were examined. A new index, the quantitative lung index (QLI) was derived using published data on HC and the area of the base of the right lung. Results: Neither the LHR nor the observed/expected LHR proved to be gestational age independent. Right lung growth can be expressed using the following formula: QLI = lung area/(HC/10)2. The 50th percentile of the QLI remained constant at approximately 1.0 for the gestational age between 16-32 weeks. A small lung (<1st percentile) was defined as a QLI <0.6. Conclusion: Fetal right lung growth can be adequately described using the QLI, independent of gestational age. Further studies are needed to assess the clinical accuracy of the QLI in characterizing fetal right lung growth.

KW - congenital diaphragmatic hernia

KW - lung-to-head circumference ratio

KW - tracheal occlusion

UR - http://www.scopus.com/inward/record.url?scp=81855166669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81855166669&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2011.07.031

DO - 10.1016/j.ajog.2011.07.031

M3 - Article

C2 - 21944224

AN - SCOPUS:81855166669

VL - 205

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -