The psoriatic epidermal lesion and anagen hair growth may share the same 'switch-on' mechanism

R. Paus, R. E. Link

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Based on striking parallels between the cell kinetics in the epidermal lesion of psoriasis and the proliferation of hair matrix keratinocytes during the anagen phase of the hair growth cycle, the hypothesis is proposed that both phenomena may share the same 'switch-on' mechanism. Particular emphasis is placed on a comparison between the Koebner phenomenon in psoriasis and wounding-induced anagen hair growth. In discussing alternative theoretical models for the proposed common 'switch-on' mechanism, some useful experimental tools are suggested. Research into the mechanisms which control epithelial proliferation in psoriasis and hair growth may provide new insights into other growth processes, such as embryonic organogenesis and neoplasia, in which similar epithelial-mesenchymal interactions play a pivotal role.

Original languageEnglish (US)
Pages (from-to)467-476
Number of pages10
JournalYale Journal of Biology and Medicine
Volume61
Issue number5
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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