The prevalence of human immunodeficiency virus type 1 and hepatitis C virus among injection drug users who use high risk inner-city locales in Miami, Florida

Clyde B McCoy, Lisa R. Metsch, Fernando Collado-Mesa, Kristopher Arheart, Sarah Messiah, Dolores Katz, Paul Shapshak

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In order to estimate the prevalence of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) co-infection in hard-to-reach intravenous drug users, 199 subjects from high-risk inner-city locales, the so called "shooting galleries", were consented, interviewed, and tested in Miami, FL, US. Positive HIV-1 status was based on repeatedly reactive ELISA and confirmatory Western Blot. Positive HCV status was based on reactive ELISA and confirmatory polymerase chain reaction techniques. Overall, 50 (25%) were not infected with either virus, 61 (31%) were HIV-1/HCV co-infected, 17 (8%) infected by HIV-1 only, and 71 (36%) infected by HCV only. The results of the multivariable analyses showed that more years using heroin was the only significant risk factor for HCV only infection (odds ratio = 1.15; 95% confidence interval = 1.07, 1.24) and for HIV-1/HCV co-infection (odds ratio = 1.17; 95% confidence interval = 1.09, 1.26). This paper demonstrates that HIV-1/HCV co-infection is highly prevalent among so called "shooting galleries".

Original languageEnglish
Pages (from-to)789-793
Number of pages5
JournalMemorias do Instituto Oswaldo Cruz
Volume99
Issue number8
StatePublished - Dec 1 2004

Fingerprint

Drug Users
Viruses
Hepacivirus
HIV-1
Injections
Virus Diseases
Pharmaceutical Preparations
Coinfection
Enzyme-Linked Immunosorbent Assay
Odds Ratio
Confidence Intervals
Heroin
Western Blotting
Polymerase Chain Reaction
Polymerase chain reaction

Keywords

  • Co-infection
  • Hepatitis C virus
  • Human immunodeficiency virus 1
  • Injection drug users

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Immunology
  • Microbiology (medical)
  • Clinical Biochemistry

Cite this

The prevalence of human immunodeficiency virus type 1 and hepatitis C virus among injection drug users who use high risk inner-city locales in Miami, Florida. / McCoy, Clyde B; Metsch, Lisa R.; Collado-Mesa, Fernando; Arheart, Kristopher; Messiah, Sarah; Katz, Dolores; Shapshak, Paul.

In: Memorias do Instituto Oswaldo Cruz, Vol. 99, No. 8, 01.12.2004, p. 789-793.

Research output: Contribution to journalArticle

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