The prevalence of fragile X in a sample of autistic individuals diagnosed using a standardized interview

Joseph Piven, Jeanne Gayle, Rebecca Landa, Maryann Wzorek, Susan Folstein

Research output: Contribution to journalArticle

38 Scopus citations


The study examined 75 autistic individuals who met DSM-III-R criteria for autistic disorder at 5 years of age. Diagnosis was based on information elicited using a standardized interview for autism. Two of 75 (2.7%) autistic subjects expressed the fragile X marker (Xq27.3) in 40% of cells counted and had other affected family members. Two additional subjects expressed the fragile X anomaly at low rates (1%). These rates are compared with those reported in other studies. Methodological differences, which may underlie the varying rates reported across studies, are discussed.

Original languageEnglish (US)
Pages (from-to)825-830
Number of pages6
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number5
StatePublished - Jan 1 1991



  • autism
  • fragile X
  • structured interview

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this