The presentation of adenocarcinoma of the uterine cervix

B. E. Miller, S. D. Flax, Kristopher Arheart, G. Photopulos

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Background. Among malignancies of the uterine cervix, the percentage of adenocarcinomas seems to have increased in recent reports. Methods. The clinical presentation of adenocarcinoma of the uterine cervix during the past 25 years was examined by review of charts and pathologic specimens. The data of a total of 124 patients with cervical adenocarcinoma treated between 1964 and 1988 were evaluated. Results. During the 25-year period, the percentage of adenocarcinoma among all cervical malignancies increased from 9% to 25%. In addition, the average number of new cases per year increased from 3.7 to 10.8. The percentage of women younger than 35 years with adenocarcinoma increased from 16% in 1964 to 24% in 1989. Of these younger women, 74% had disease discovered by cytopathology, in comparison with 27% of the patients who were older than 35 years. The overall percentage of patients with disease diagnosed by cytology increased from 24% in the first half to 39% in the second half of the study period. Vaginal bleeding was the most common symptom. In the entire period, 57% of patients had International Federation of Gynecology and Obstetrics (FIGO) Stage I disease, with a median tumor diameter of 1 cm in patients with no symptoms and 3 cm in patients with symptoms. Outcome was inversely related to stage, tumor volume, and the presence of lymph node metastasis but not to histologic tumor type. Conclusion. The frequency of adenocarcinoma of uterine cervix is increasing in patients 35 years or younger. Cytopathology is a good screening tool for these patients, leading to earlier diagnosis and improved outcome.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalCancer
Volume72
Issue number4
StatePublished - Jan 1 1993
Externally publishedYes

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Cervix Uteri
Adenocarcinoma
Neoplasms
Uterine Hemorrhage
Tumor Burden
Gynecology
Obstetrics
Cell Biology
Early Diagnosis
Lymph Nodes
Neoplasm Metastasis

Keywords

  • adenocarcinoma
  • clinical presentation
  • uterine cervix

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Miller, B. E., Flax, S. D., Arheart, K., & Photopulos, G. (1993). The presentation of adenocarcinoma of the uterine cervix. Cancer, 72(4), 1281-1285.

The presentation of adenocarcinoma of the uterine cervix. / Miller, B. E.; Flax, S. D.; Arheart, Kristopher; Photopulos, G.

In: Cancer, Vol. 72, No. 4, 01.01.1993, p. 1281-1285.

Research output: Contribution to journalArticle

Miller, BE, Flax, SD, Arheart, K & Photopulos, G 1993, 'The presentation of adenocarcinoma of the uterine cervix', Cancer, vol. 72, no. 4, pp. 1281-1285.
Miller BE, Flax SD, Arheart K, Photopulos G. The presentation of adenocarcinoma of the uterine cervix. Cancer. 1993 Jan 1;72(4):1281-1285.
Miller, B. E. ; Flax, S. D. ; Arheart, Kristopher ; Photopulos, G. / The presentation of adenocarcinoma of the uterine cervix. In: Cancer. 1993 ; Vol. 72, No. 4. pp. 1281-1285.
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