The presence of only one of five exoribonucleases is sufficient to support the growth of Escherichia coli

K. O. Kelly, M. P. Deutscher

Research output: Contribution to journalComment/debate

45 Scopus citations


Escherichia coli contains multiple exoribonucleases. Strains lacking the exoribonucleases RNase II, D, BN, T, and PH are inviable. The introduction of a chromosomal, wild-type copy of the gene for any one of these enzymes is sufficient to allow cell growth, with the enzymes being in the following order of effectiveness: RNase T > RNase PH > RNase D > RNase II > RNase BN. The data indicate that these five exoribonucleases functionally overlap in vivo and that any one of them can take over the functions of all the others, although with various efficiencies.

Original languageEnglish (US)
Pages (from-to)6682-6684
Number of pages3
JournalJournal of Bacteriology
Issue number20
StatePublished - Jan 1 1992


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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