TY - JOUR
T1 - The presence of antithyroid antibodies in patients with affective and nonaffective psychiatric disorders
AU - Haggerty, John J.
AU - Evans, Dwight L.
AU - Golden, Robert N.
AU - Pedersen, Cort A.
AU - Simon, Jeffrey S.
AU - Nemeroff, Charles B.
N1 - Funding Information:
From the Departments of Psychiatry (\].J.H.Jr., D.L.E, R.N.G., C.A.P.) and Medicine (D.L.E.), University of North Carolina School of Medicine, Chapel Hill, NC; the Department of Psychiatry, University of Wisconsin Medical School~ Milw~,ukee Cli,~ic~l Campus, Milwaukee, WI (LS.S.); and the Departments of Psychiatry and Pharmacology, Duke University School of Medicine, Durhan, NC (C.B.N.). Supported in part by NIMH Grants MH4256-34622, 33127-09, MH42625-01, and by the Foundation of Hope, Raleigh, North Carolina. Presented in part at the 42nd Annual Meeting of the Society of Biological Psychiarty, Chicago, Illinois, May 7-10, 1987, and at the 140th Annual Meeting of the American Psycmatric Association, Chicago, Illinois, May I 1-15, 1987. Address reprint requests to John J. Haggerty, Jr., M.D. Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27514. Received March II, 1988; revised January 19, 1989.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - We determined the frequency of antihyroglobulin and antimicrosomal antibodies in 173 consecutively admitted psychiatric inpatients. (We found antihydroid antibodies in 8% (5/65) of patients with DSM-III major depression, 13% (4/31) with bipolar disorder, and in 0% (0/4) of those with schizoaffective disorder.) The rate of antibody occurrence was unrelated to lithium exposure either within individual diagnostic categories or for the sample as a whole. The overall frequency of positive antihydroid antibody titers in patients with DSM-III affective disorder, 9% (9/99), did not differ from that in patients with nonaffective disorders, 10% (7/68). However, patients with bipolar affective disorder-mixed or bipolar affective disorder-depressed had a higher rate of positive antithyroid antibody titers than other patients. Our findings confirm earlier reports that thyroid disorders may be particularly common in patients with bipolar affective disorder, even in the absence of lithium exposure. However, as antithyroid antibodies also occurred at a relatively high rate in nonaffective disorders, the possible psychiatric effects of autoimmune thyroiditis do not appear to be limited to affective dysregulation.
AB - We determined the frequency of antihyroglobulin and antimicrosomal antibodies in 173 consecutively admitted psychiatric inpatients. (We found antihydroid antibodies in 8% (5/65) of patients with DSM-III major depression, 13% (4/31) with bipolar disorder, and in 0% (0/4) of those with schizoaffective disorder.) The rate of antibody occurrence was unrelated to lithium exposure either within individual diagnostic categories or for the sample as a whole. The overall frequency of positive antihydroid antibody titers in patients with DSM-III affective disorder, 9% (9/99), did not differ from that in patients with nonaffective disorders, 10% (7/68). However, patients with bipolar affective disorder-mixed or bipolar affective disorder-depressed had a higher rate of positive antithyroid antibody titers than other patients. Our findings confirm earlier reports that thyroid disorders may be particularly common in patients with bipolar affective disorder, even in the absence of lithium exposure. However, as antithyroid antibodies also occurred at a relatively high rate in nonaffective disorders, the possible psychiatric effects of autoimmune thyroiditis do not appear to be limited to affective dysregulation.
UR - http://www.scopus.com/inward/record.url?scp=0025099072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025099072&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(90)90019-X
DO - 10.1016/0006-3223(90)90019-X
M3 - Article
C2 - 2297552
AN - SCOPUS:0025099072
VL - 27
SP - 51
EP - 60
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -