The potential impact of integrated malaria transmission control on entomologic inoculation rate in highly endemic areas

G. E. Killeen, F. E. McKenzie, B. D. Foy, C. Schieffelin, P. E. Billingsley, John C Beier

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

We have used a relatively simple but accurate model for predicting the impact of integrated transmission control on the malaria entomologic inoculation rate (EIR) at four endemic sites from across sub-Saharan Africa and the southwest Pacific. The simulated campaign incorporated modestly effective vaccine coverage, bed net use, and larval control. The results indicate that such campaigns would reduce EIRs at all four sites by 30- to 50-fold. Even without the vaccine, 15- to 25-fold reductions of EIR were predicted, implying that integrated control with a few modestly effective tools can meaningfully reduce malaria transmission in a range of endemic settings. The model accurately predicts the effects of bed nets and indoor spraying and demonstrates that they are the most effective tools available for reducing EIR. However, the impact of domestic adult vector control is amplified by measures for reducing the rate of emergence of vectors or the level of infectiousness of the human reservoir. We conclude that available tools, including currently neglected methods for larval control, can reduce malaria transmission intensity enough to alleviate mortality. Integrated control programs should be implemented to the fullest extent possible, even in areas of intense transmission, using simple models as decision-making tools. However, we also conclude that to eliminate malaria in many areas of intense transmission is beyond the scope of methods which developing nations can currently afford. New, cost-effective, practical tools are needed if malaria is ever to be eliminated from highly endemic areas.

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume62
Issue number5
StatePublished - Dec 1 2000
Externally publishedYes

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Malaria
Vaccines
Africa South of the Sahara
Developing Countries
Decision Making
Costs and Cost Analysis
Mortality

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

The potential impact of integrated malaria transmission control on entomologic inoculation rate in highly endemic areas. / Killeen, G. E.; McKenzie, F. E.; Foy, B. D.; Schieffelin, C.; Billingsley, P. E.; Beier, John C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 62, No. 5, 01.12.2000, p. 545-551.

Research output: Contribution to journalArticle

Killeen, G. E. ; McKenzie, F. E. ; Foy, B. D. ; Schieffelin, C. ; Billingsley, P. E. ; Beier, John C. / The potential impact of integrated malaria transmission control on entomologic inoculation rate in highly endemic areas. In: American Journal of Tropical Medicine and Hygiene. 2000 ; Vol. 62, No. 5. pp. 545-551.
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