The pituitary response to ovine corticotropin-releasing hormone is enhanced in obese men and correlates with insulin resistance

M. P. Solano, M. Kumar, B. Fernandez, L. Jones, R. B. Goldberg

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in central obesity has been demonstrated in women. We studied the corticotropin (ACTH) and cortisol response to ovine corticotropin releasing hormone (oCRH) and its association to parameters of adiposity and insulin resistance in a group of 19 healthy obese (BMI > 25 kg/m2) and 9 non-obese men. Relative insulin resistance was assessed by the homeostatic model assessment (HOMA IR). Baseline ACTH was similar, while cortisol was lower in the obese group. The ACTH response to oCRH was significantly higher in the obese group. ACTH incremental area under the curve (iAUC) correlated with age, HOMA IR, and sagittal diameter but not with leptin. In multiple regression analysis, only HOMA IR was an independent predictor of ACTH iAUC. In conclusion, obese men have hyperactivity of the HPA axis at the pituitary level, which appears to be linked to insulin resistance.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalHormone and Metabolic Research
Volume33
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Central Obesity
  • HPA Axis
  • Insulin Resistance

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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