TY - JOUR
T1 - The PERG in diabetic glaucoma suspects with no evidence of retinopathy
AU - Ventura, Lori M.
AU - Golubev, Iuri
AU - Feuer, William J.
AU - Porciatti, Vittorio
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/4
Y1 - 2010/4
N2 - Objective: To better understand the role of diabetes mellitus on retinal ganglion cell function of glaucoma suspects. Methods: Eighteen diabetic glaucoma suspects (GSD) without retinopathy (type-2, n=16, type-1, n=2) and 156 age-matched glaucoma suspects (GS) without diabetes were tested with steady-state pattern electroretinogram (PERG, PERGLA paradigm, Ophthalmology 2004,111:161) as surrogate measure of retinal ganglion cell function. Results were compared with previously published data of 48 similarly aged normal controls (NC). All subjects (NC, GS, GSD) had small refractive errors and corrected visual acuity ≥20/25. Results: The mean PERG amplitude of both GS and GSD was significantly (P<0.01) smaller than that of age-matched NC. The mean PERG amplitude of GSD patients was significantly (P<0.05) smaller than that of GS accounting for individual differences in age, visual acuity, visual field defect, and intraocular pressure. The mean PERG phase did not differ between GS and GSD. Conclusions: In agreement with previous studies, our results show that on average, GS have reduced PERG amplitude compared with NC. PERG amplitude is further reduced in GSD compared with nondiabetic GS with otherwise comparable ophthalmologic and systemic conditions.
AB - Objective: To better understand the role of diabetes mellitus on retinal ganglion cell function of glaucoma suspects. Methods: Eighteen diabetic glaucoma suspects (GSD) without retinopathy (type-2, n=16, type-1, n=2) and 156 age-matched glaucoma suspects (GS) without diabetes were tested with steady-state pattern electroretinogram (PERG, PERGLA paradigm, Ophthalmology 2004,111:161) as surrogate measure of retinal ganglion cell function. Results were compared with previously published data of 48 similarly aged normal controls (NC). All subjects (NC, GS, GSD) had small refractive errors and corrected visual acuity ≥20/25. Results: The mean PERG amplitude of both GS and GSD was significantly (P<0.01) smaller than that of age-matched NC. The mean PERG amplitude of GSD patients was significantly (P<0.05) smaller than that of GS accounting for individual differences in age, visual acuity, visual field defect, and intraocular pressure. The mean PERG phase did not differ between GS and GSD. Conclusions: In agreement with previous studies, our results show that on average, GS have reduced PERG amplitude compared with NC. PERG amplitude is further reduced in GSD compared with nondiabetic GS with otherwise comparable ophthalmologic and systemic conditions.
KW - Diabetes
KW - Glaucoma
KW - Pattern electroretinogram
KW - Retinal ganglion cell function
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U2 - 10.1097/IJG.0b013e3181a990ea
DO - 10.1097/IJG.0b013e3181a990ea
M3 - Article
C2 - 19528818
AN - SCOPUS:77951488893
VL - 19
SP - 243
EP - 247
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
IS - 4
ER -