The pendulum swings: Tolerance versus priming to NIMA

Shannon J. Opiela, Becky Adkins

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Fetal and/or perinatal exposure to noninherited maternal antigens (NIMA) has been reported to induce NIMA-specific tolerance. This tolerant state is highly beneficial in transplantation settings; enhanced graft acceptance has been observed when transplanted tissues express NIMA. Reduction in severe graft-vs-host disease has also been noted when bone marrow grafts originate from donors exposed to NIMA in early life. However, there is emerging evidence that exposure to NIMA can alternatively lead to specific priming. The processes regulating tolerance versus priming to NI MA are poorly understood and probably multifactorial. Based on studies in both humans and mice, we propose that both the quality and the quantity of NIMA exposure will be found to be key determinants of these opposing outcomes.

Original languageEnglish (US)
Pages (from-to)36-38
Number of pages3
JournalChimerism
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Breast milk
  • In utero
  • NIMA
  • Noninherited maternal antigens
  • Priming
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Biochemistry
  • Genetics
  • Molecular Biology

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