The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods

Meyer Kattan, Hannah Peavy, Anthony Kalica, Carol Kasten-Sportes, Elaine Sloand, George Sopko, Carol Vreim, Constance Weinstein, Margaret Wu, Robert Mellins, William Shearer, Stuart Abramson, Nancy Ayres, Carol Baker, J. Timothy Bricker, Gail Demmler, Marilyn Doyle, Maynard Dyson, Janet Englund, Nancy EriksenArthur Garson, Bernard Gonik, Hunter Hammill, Thomas Hansen, I. Celine Hanson, Peter Hiatt, Keith Hoots, Robert Jacobson, Debra Kearney, Mark Kline, C. Claudia Kozinetz, Claire Langston, C. Lapin, Achi Ludomirsky, Warren Moore, Lawrence Pickering, Howard Rosenblatt, Edward Singleton, Larry Taber, Theresa Aldape, Deborah Brinsdon, Nancy Calles, Madeline Cantini, Linda Davis, Kim Evans, Paula Feinman, David Flores, Alison Istas, Sharon Haymore, Suzanne Kirkpatrick, Jill Laflen, Lisa Luedtke, Mary Beth Mauer, Cheryl Maurice, Chuck Mazac, Ruth McConnell, Laurence McKinney, Debra Mooneyham, Cathy Murtagh, Valerie Nichols, Kelly O'Donnell, Sherryon Sterling, Teresa Tonsberg, Denise Treece, Pam Weaver, Steven Lipshultz, I. Inas Al-Attar, Robert Cleveland, Steven Colan, Andrew Colin, Ellen Cooper, William Cranley, Thorn Griscom, Lisa Hornberger, John Kasznica, Kenneth McIntosh, Tracie Miller, E. John Orav, Steven Pelton, Antonio Perez-Atayde, Stephen Saunders, Marcy Schwartz, Suzanne Steinbach, S. Ted Treves, Ruth Tuomala, Mary Ellen Wohl, Cynthia Barber, Roxellen Bayer, Ann Marie Boller, Nancy Borden, Pamela D'Arcy, Rachel Diness, Helen Donovan, Sartreina Dottin, Julie Druker, Mary Ford, Cheryl Gothing, Nina Greenbaum, Lisa Heughan

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The P2C2 HIV Study is a prospective natural history study initiated by the National Heart, Lung, and Blood Institute in order to describe the types and incidence of cardiovascular and pulmonary disorders that occur in children with vertically transmitted HIV infection (i.e., transmitted from mother to child in utero or perinatally). This article describes the study design and methods. Patients were recruited from five clinical centers in the United States. The cohort is composed of 205 infants and children enrolled after 28 days of age (Group I) and 612 fetuses and infants of HIV-infected mothers, enrolled prenatally (73%) or postnatally at age < 28 days (Group II). The maternal-to-infant transmission rate in Group II was 17%. The HIV-negative infants in Group II (Group IIb) serves as a control group for the HIV infected children (Group IIa). The cohort is followed at specified intervals for clinical examination, cardiac, pulmonary, immunologic, and infectious studies and for intercurrent illnesses. In Group IIa, the cumulative loss-to-follow-up rate at 3 years was 10.5%, and the 3-year cumulative mortality rate was 24.9%. The findings will be relevant to clinical and epidemiologic aspects of HIV infection in children.

Original languageEnglish (US)
Pages (from-to)1285-1294
Number of pages10
JournalJournal of Clinical Epidemiology
Volume49
Issue number11
DOIs
StatePublished - Nov 1996

Keywords

  • Cardiovascular complications
  • HIV
  • Pediatric AIDS
  • Prospective study
  • Pulmonary complications
  • Vertical transmission

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

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    Kattan, M., Peavy, H., Kalica, A., Kasten-Sportes, C., Sloand, E., Sopko, G., Vreim, C., Weinstein, C., Wu, M., Mellins, R., Shearer, W., Abramson, S., Ayres, N., Baker, C., Bricker, J. T., Demmler, G., Doyle, M., Dyson, M., Englund, J., ... Heughan, L. (1996). The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods. Journal of Clinical Epidemiology, 49(11), 1285-1294. https://doi.org/10.1016/S0895-4356(96)00230-2