The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods

Meyer Kattan, Hannah Peavy, Anthony Kalica, Carol Kasten-Sportes, Elaine Sloand, George Sopko, Carol Vreim, Constance Weinstein, Margaret Wu, Robert Mellins, William Shearer, Stuart Abramson, Nancy Ayres, Carol Baker, J. Timothy Bricker, Gail Demmler, Marilyn Doyle, Maynard Dyson, Janet Englund, Nancy EriksenArthur Garson, Bernard Gonik, Hunter Hammill, Thomas Hansen, I. Celine Hanson, Peter Hiatt, Keith Hoots, Robert Jacobson, Debra Kearney, Mark Kline, C. Claudia Kozinetz, Claire Langston, C. Lapin, Achi Ludomirsky, Warren Moore, Lawrence Pickering, Howard Rosenblatt, Edward Singleton, Larry Taber, Theresa Aldape, Deborah Brinsdon, Nancy Calles, Madeline Cantini, Linda Davis, Kim Evans, Paula Feinman, David Flores, Alison Istas, Sharon Haymore, Suzanne Kirkpatrick, Jill Laflen, Lisa Luedtke, Mary Beth Mauer, Cheryl Maurice, Chuck Mazac, Ruth McConnell, Laurence McKinney, Debra Mooneyham, Cathy Murtagh, Valerie Nichols, Kelly O'Donnell, Sherryon Sterling, Teresa Tonsberg, Denise Treece, Pam Weaver, Steven E Lipshultz, I. Inas Al-Attar, Robert Cleveland, Steven Colan, Andrew Colin, Ellen Cooper, William Cranley, Thorn Griscom, Lisa Hornberger, John Kasznica, Kenneth McIntosh, Tracie L Miller, E. John Orav, Steven Pelton, Antonio Perez-Atayde, Stephen Saunders, Marcy Schwartz, Suzanne Steinbach, S. Ted Treves, Ruth Tuomala, Mary Ellen Wohl, Cynthia Barber, Roxellen Bayer, Ann Marie Boller, Nancy Borden, Pamela D'Arcy, Rachel Diness, Helen Donovan, Sartreina Dottin, Julie Druker, Mary Ford, Cheryl Gothing, Nina Greenbaum, Lisa Heughan

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The P2C2 HIV Study is a prospective natural history study initiated by the National Heart, Lung, and Blood Institute in order to describe the types and incidence of cardiovascular and pulmonary disorders that occur in children with vertically transmitted HIV infection (i.e., transmitted from mother to child in utero or perinatally). This article describes the study design and methods. Patients were recruited from five clinical centers in the United States. The cohort is composed of 205 infants and children enrolled after 28 days of age (Group I) and 612 fetuses and infants of HIV-infected mothers, enrolled prenatally (73%) or postnatally at age < 28 days (Group II). The maternal-to-infant transmission rate in Group II was 17%. The HIV-negative infants in Group II (Group IIb) serves as a control group for the HIV infected children (Group IIa). The cohort is followed at specified intervals for clinical examination, cardiac, pulmonary, immunologic, and infectious studies and for intercurrent illnesses. In Group IIa, the cumulative loss-to-follow-up rate at 3 years was 10.5%, and the 3-year cumulative mortality rate was 24.9%. The findings will be relevant to clinical and epidemiologic aspects of HIV infection in children.

Original languageEnglish
Pages (from-to)1285-1294
Number of pages10
JournalJournal of Clinical Epidemiology
Volume49
Issue number11
DOIs
StatePublished - Nov 1 1996
Externally publishedYes

Fingerprint

HIV Infections
HIV
Pediatrics
Lung
Mothers
National Heart, Lung, and Blood Institute (U.S.)
Natural History
Fetus
Age Groups
Control Groups
Mortality
Incidence

Keywords

  • Cardiovascular complications
  • HIV
  • Pediatric AIDS
  • Prospective study
  • Pulmonary complications
  • Vertical transmission

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study : Design and methods. / Kattan, Meyer; Peavy, Hannah; Kalica, Anthony; Kasten-Sportes, Carol; Sloand, Elaine; Sopko, George; Vreim, Carol; Weinstein, Constance; Wu, Margaret; Mellins, Robert; Shearer, William; Abramson, Stuart; Ayres, Nancy; Baker, Carol; Bricker, J. Timothy; Demmler, Gail; Doyle, Marilyn; Dyson, Maynard; Englund, Janet; Eriksen, Nancy; Garson, Arthur; Gonik, Bernard; Hammill, Hunter; Hansen, Thomas; Hanson, I. Celine; Hiatt, Peter; Hoots, Keith; Jacobson, Robert; Kearney, Debra; Kline, Mark; Kozinetz, C. Claudia; Langston, Claire; Lapin, C.; Ludomirsky, Achi; Moore, Warren; Pickering, Lawrence; Rosenblatt, Howard; Singleton, Edward; Taber, Larry; Aldape, Theresa; Brinsdon, Deborah; Calles, Nancy; Cantini, Madeline; Davis, Linda; Evans, Kim; Feinman, Paula; Flores, David; Istas, Alison; Haymore, Sharon; Kirkpatrick, Suzanne; Laflen, Jill; Luedtke, Lisa; Mauer, Mary Beth; Maurice, Cheryl; Mazac, Chuck; McConnell, Ruth; McKinney, Laurence; Mooneyham, Debra; Murtagh, Cathy; Nichols, Valerie; O'Donnell, Kelly; Sterling, Sherryon; Tonsberg, Teresa; Treece, Denise; Weaver, Pam; Lipshultz, Steven E; Al-Attar, I. Inas; Cleveland, Robert; Colan, Steven; Colin, Andrew; Cooper, Ellen; Cranley, William; Griscom, Thorn; Hornberger, Lisa; Kasznica, John; McIntosh, Kenneth; Miller, Tracie L; Orav, E. John; Pelton, Steven; Perez-Atayde, Antonio; Saunders, Stephen; Schwartz, Marcy; Steinbach, Suzanne; Treves, S. Ted; Tuomala, Ruth; Wohl, Mary Ellen; Barber, Cynthia; Bayer, Roxellen; Boller, Ann Marie; Borden, Nancy; D'Arcy, Pamela; Diness, Rachel; Donovan, Helen; Dottin, Sartreina; Druker, Julie; Ford, Mary; Gothing, Cheryl; Greenbaum, Nina; Heughan, Lisa.

In: Journal of Clinical Epidemiology, Vol. 49, No. 11, 01.11.1996, p. 1285-1294.

Research output: Contribution to journalArticle

Kattan, M, Peavy, H, Kalica, A, Kasten-Sportes, C, Sloand, E, Sopko, G, Vreim, C, Weinstein, C, Wu, M, Mellins, R, Shearer, W, Abramson, S, Ayres, N, Baker, C, Bricker, JT, Demmler, G, Doyle, M, Dyson, M, Englund, J, Eriksen, N, Garson, A, Gonik, B, Hammill, H, Hansen, T, Hanson, IC, Hiatt, P, Hoots, K, Jacobson, R, Kearney, D, Kline, M, Kozinetz, CC, Langston, C, Lapin, C, Ludomirsky, A, Moore, W, Pickering, L, Rosenblatt, H, Singleton, E, Taber, L, Aldape, T, Brinsdon, D, Calles, N, Cantini, M, Davis, L, Evans, K, Feinman, P, Flores, D, Istas, A, Haymore, S, Kirkpatrick, S, Laflen, J, Luedtke, L, Mauer, MB, Maurice, C, Mazac, C, McConnell, R, McKinney, L, Mooneyham, D, Murtagh, C, Nichols, V, O'Donnell, K, Sterling, S, Tonsberg, T, Treece, D, Weaver, P, Lipshultz, SE, Al-Attar, II, Cleveland, R, Colan, S, Colin, A, Cooper, E, Cranley, W, Griscom, T, Hornberger, L, Kasznica, J, McIntosh, K, Miller, TL, Orav, EJ, Pelton, S, Perez-Atayde, A, Saunders, S, Schwartz, M, Steinbach, S, Treves, ST, Tuomala, R, Wohl, ME, Barber, C, Bayer, R, Boller, AM, Borden, N, D'Arcy, P, Diness, R, Donovan, H, Dottin, S, Druker, J, Ford, M, Gothing, C, Greenbaum, N & Heughan, L 1996, 'The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods', Journal of Clinical Epidemiology, vol. 49, no. 11, pp. 1285-1294. https://doi.org/10.1016/S0895-4356(96)00230-2
Kattan, Meyer ; Peavy, Hannah ; Kalica, Anthony ; Kasten-Sportes, Carol ; Sloand, Elaine ; Sopko, George ; Vreim, Carol ; Weinstein, Constance ; Wu, Margaret ; Mellins, Robert ; Shearer, William ; Abramson, Stuart ; Ayres, Nancy ; Baker, Carol ; Bricker, J. Timothy ; Demmler, Gail ; Doyle, Marilyn ; Dyson, Maynard ; Englund, Janet ; Eriksen, Nancy ; Garson, Arthur ; Gonik, Bernard ; Hammill, Hunter ; Hansen, Thomas ; Hanson, I. Celine ; Hiatt, Peter ; Hoots, Keith ; Jacobson, Robert ; Kearney, Debra ; Kline, Mark ; Kozinetz, C. Claudia ; Langston, Claire ; Lapin, C. ; Ludomirsky, Achi ; Moore, Warren ; Pickering, Lawrence ; Rosenblatt, Howard ; Singleton, Edward ; Taber, Larry ; Aldape, Theresa ; Brinsdon, Deborah ; Calles, Nancy ; Cantini, Madeline ; Davis, Linda ; Evans, Kim ; Feinman, Paula ; Flores, David ; Istas, Alison ; Haymore, Sharon ; Kirkpatrick, Suzanne ; Laflen, Jill ; Luedtke, Lisa ; Mauer, Mary Beth ; Maurice, Cheryl ; Mazac, Chuck ; McConnell, Ruth ; McKinney, Laurence ; Mooneyham, Debra ; Murtagh, Cathy ; Nichols, Valerie ; O'Donnell, Kelly ; Sterling, Sherryon ; Tonsberg, Teresa ; Treece, Denise ; Weaver, Pam ; Lipshultz, Steven E ; Al-Attar, I. Inas ; Cleveland, Robert ; Colan, Steven ; Colin, Andrew ; Cooper, Ellen ; Cranley, William ; Griscom, Thorn ; Hornberger, Lisa ; Kasznica, John ; McIntosh, Kenneth ; Miller, Tracie L ; Orav, E. John ; Pelton, Steven ; Perez-Atayde, Antonio ; Saunders, Stephen ; Schwartz, Marcy ; Steinbach, Suzanne ; Treves, S. Ted ; Tuomala, Ruth ; Wohl, Mary Ellen ; Barber, Cynthia ; Bayer, Roxellen ; Boller, Ann Marie ; Borden, Nancy ; D'Arcy, Pamela ; Diness, Rachel ; Donovan, Helen ; Dottin, Sartreina ; Druker, Julie ; Ford, Mary ; Gothing, Cheryl ; Greenbaum, Nina ; Heughan, Lisa. / The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study : Design and methods. In: Journal of Clinical Epidemiology. 1996 ; Vol. 49, No. 11. pp. 1285-1294.
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AU - Kattan, Meyer

AU - Peavy, Hannah

AU - Kalica, Anthony

AU - Kasten-Sportes, Carol

AU - Sloand, Elaine

AU - Sopko, George

AU - Vreim, Carol

AU - Weinstein, Constance

AU - Wu, Margaret

AU - Mellins, Robert

AU - Shearer, William

AU - Abramson, Stuart

AU - Ayres, Nancy

AU - Baker, Carol

AU - Bricker, J. Timothy

AU - Demmler, Gail

AU - Doyle, Marilyn

AU - Dyson, Maynard

AU - Englund, Janet

AU - Eriksen, Nancy

AU - Garson, Arthur

AU - Gonik, Bernard

AU - Hammill, Hunter

AU - Hansen, Thomas

AU - Hanson, I. Celine

AU - Hiatt, Peter

AU - Hoots, Keith

AU - Jacobson, Robert

AU - Kearney, Debra

AU - Kline, Mark

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AU - Ludomirsky, Achi

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AU - Pickering, Lawrence

AU - Rosenblatt, Howard

AU - Singleton, Edward

AU - Taber, Larry

AU - Aldape, Theresa

AU - Brinsdon, Deborah

AU - Calles, Nancy

AU - Cantini, Madeline

AU - Davis, Linda

AU - Evans, Kim

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AU - Flores, David

AU - Istas, Alison

AU - Haymore, Sharon

AU - Kirkpatrick, Suzanne

AU - Laflen, Jill

AU - Luedtke, Lisa

AU - Mauer, Mary Beth

AU - Maurice, Cheryl

AU - Mazac, Chuck

AU - McConnell, Ruth

AU - McKinney, Laurence

AU - Mooneyham, Debra

AU - Murtagh, Cathy

AU - Nichols, Valerie

AU - O'Donnell, Kelly

AU - Sterling, Sherryon

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AU - Treece, Denise

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AU - Al-Attar, I. Inas

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AU - Colan, Steven

AU - Colin, Andrew

AU - Cooper, Ellen

AU - Cranley, William

AU - Griscom, Thorn

AU - Hornberger, Lisa

AU - Kasznica, John

AU - McIntosh, Kenneth

AU - Miller, Tracie L

AU - Orav, E. John

AU - Pelton, Steven

AU - Perez-Atayde, Antonio

AU - Saunders, Stephen

AU - Schwartz, Marcy

AU - Steinbach, Suzanne

AU - Treves, S. Ted

AU - Tuomala, Ruth

AU - Wohl, Mary Ellen

AU - Barber, Cynthia

AU - Bayer, Roxellen

AU - Boller, Ann Marie

AU - Borden, Nancy

AU - D'Arcy, Pamela

AU - Diness, Rachel

AU - Donovan, Helen

AU - Dottin, Sartreina

AU - Druker, Julie

AU - Ford, Mary

AU - Gothing, Cheryl

AU - Greenbaum, Nina

AU - Heughan, Lisa

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KW - Cardiovascular complications

KW - HIV

KW - Pediatric AIDS

KW - Prospective study

KW - Pulmonary complications

KW - Vertical transmission

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