The pathology of metabolic bone disease

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Although metabolic bone diseases are associated with a disparate array of pathologic conditions, their skeletal manifestations all result from dysfunction of osteoblasts and osteoclasts and abnormal rates of mineralization. Understanding their pathology helps one appreciate their radiographic characteristics. Some of the common metabolic bone diseases, such as osteoporosis and hyperparathyroidism, may be diagnosed by routine light microscopy; however, many require the evaluation of undecalcified bone specimens by sophisticated histomorphometric techniques. Osteopetrosis and osteogenesis imperfecta and other rarer forms of metabolic diseases frequently have a genetic mode of transmission, and advances in molecular biology have led to the identification of their pathogenesis.

Original languageEnglish (US)
Pages (from-to)19-36
Number of pages18
JournalRadiologic Clinics of North America
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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