The pathogenesis of Chiari I malformation and syringomyelia

Raymond F. Sekula, Gregory D. Arnone, Christine Crocker, Khaled M. Aziz, Noam Alperin

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Objective: The pathogeneses of Chiari malformation type I and syringomyelia are incompletely understood. In this article, the authors attempt to review the current theories on the pathogeneses of Chiari I malformation and syringomyelia. Methods: A literature review for articles pertaining to Chiari I malformation or syringomyelia before August 2010 was conducted; in addition, the author's own experience in treating Chiari I malformation and syringomyelia is included. Results: Chiari I malformation has been defined radiographically as cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum. By this narrow definition, Chiari I malformation (i.e. cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum) likely encompasses a heterogeneous grouping of disorders caused by different mechanisms. Molecular and genetic studies have been helpful in furthering our understanding of Chiari I malformation. Conclusion: A review of the pathogeneses of Chiari I malformation and syringomyelia is reported.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalNeurological Research
Volume33
Issue number3
DOIs
StatePublished - Apr 2011

Keywords

  • Cerebellar tonsillar ectopia
  • Chiari malformation
  • Pathogenesis
  • Syringomyelia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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