The paraoxonase gene family and atherosclerosis

David Seo, Pascal Goldschmidt-Clermont

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Management of serum low-density lipoprotein has been a cornerstone of cardiovascular medicine for the past two decades. More recently, the attention paid to the protective role of high-density lipoprotein (HDL) in atherosclerosis has increased substantially, particularly with respect to the antioxidant properties of HDL. Considerable evidence supports the notion that the paraoxonase gene family is largely responsible for the antioxidant properties of HDL. This article reviews the three known members of the paraoxonase family and the evidence that supports their likely role in the development and progression of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalCurrent atherosclerosis reports
Issue number3
StatePublished - 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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