The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

Olivia Osborne, Nadia Peyravian, Madhavan Nair, Sylvia Daunert, Michal Toborek

Research output: Contribution to journalReview articlepeer-review

Abstract

HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB further potentiates viral replication within the CNS, which can lead to HIV-associated neuropathology. Antiretroviral therapy (ART) significantly improves HIV patient outcomes and reduces mortality rates. However, there has been limited progress in targeting latent viral reservoirs within the CNS, which may eventually lead to rebound viremia. While ART drugs are shown to be effective in attenuating HIV replication in the periphery, the protection of the brain by the BBB offers an isolated sanctuary to harbor HIV and maintains chronic and persistent replication within the CNS. In this review, we elucidate the pathology of the BBB, its ability to potentiate viral replication, as well as current therapies and insufficiencies in treating HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)695-708
Number of pages14
JournalTrends in Neurosciences
Volume43
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • HIV
  • antiretroviral therapy
  • blood–brain barrier
  • drug delivery
  • nanomedicine

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies'. Together they form a unique fingerprint.

Cite this