The pancreatic islet as a signaling hub

Christopher J. Barker, Ingo B. Leibiger, Per Olof Berggren

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Over the last two decades we have focused on beta cell signal transduction, bringing many new insights, especially in the context of insulin signal transduction, the role of inositol polyphosphates and the regulation of cytoplasmic free Ca2+ concentration. However, there has been a growing awareness that the beta cell, which is mandatory for insulin secretion, has a unique context within the micro-organ of the pancreatic Islet of Langerhans. In this environment the beta cell both mediates and receives paracrine regulation, critical for the control of blood glucose homeostasis. Failure of an appropriate beta cell function leads to the development of diabetes mellitus.In our quest to understand the molecular events maintaining beta cell function we have faced two key challenges. Firstly, whilst there are many similarities between signal transduction in pancreatic islets between the much used rodent models and humans there are some notable differences. Critical distinctions between rodent and primate can be made in the structure of the islet, including the arrangement of the islet cells, the innervation pattern and the microcirculation. This means that important signaling interactions between islets cells, mediated through for example insulin, glucagon, GABA, glutamate and ATP, will have a unique human framework. The second challenge was to be able to take the discoveries we have made using in vitro systems and examine them in an in vivo context. Advances in in vivo imaging achieved by utilizing the anterior chamber of the eye as a transplantation site for pancreatic islets make it possible for non-invasive, longitudinal studies at single cell resolution in real time of islet cell physiology and pathology. Thus it is becoming possible to study the insulin secreting pancreatic beta cell within the framework of the unique micro-organ, the Islet of Langerhans, for the first time in a physiological context, i.e. when being innervated and connected to the blood supply.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalAdvances in Biological Regulation
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Islets of Langerhans
Signal Transduction
Insulin-Secreting Cells
Insulin
Rodentia
Cell Physiological Phenomena
Polyphosphates
Islets of Langerhans Transplantation
Anterior Chamber
Inositol
Microcirculation
Glucagon
gamma-Aminobutyric Acid
Primates
Longitudinal Studies
Blood Glucose
Glutamic Acid
Diabetes Mellitus
Homeostasis
Adenosine Triphosphate

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Barker, C. J., Leibiger, I. B., & Berggren, P. O. (2013). The pancreatic islet as a signaling hub. Advances in Biological Regulation, 53(1), 156-163. https://doi.org/10.1016/j.jbior.2012.09.011

The pancreatic islet as a signaling hub. / Barker, Christopher J.; Leibiger, Ingo B.; Berggren, Per Olof.

In: Advances in Biological Regulation, Vol. 53, No. 1, 01.01.2013, p. 156-163.

Research output: Contribution to journalArticle

Barker, CJ, Leibiger, IB & Berggren, PO 2013, 'The pancreatic islet as a signaling hub', Advances in Biological Regulation, vol. 53, no. 1, pp. 156-163. https://doi.org/10.1016/j.jbior.2012.09.011
Barker, Christopher J. ; Leibiger, Ingo B. ; Berggren, Per Olof. / The pancreatic islet as a signaling hub. In: Advances in Biological Regulation. 2013 ; Vol. 53, No. 1. pp. 156-163.
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