TY - JOUR
T1 - The pancreatic beta cell as a paradigm for advances in inositide research
AU - Barker, Christopher J.
AU - Berggren, Per Olof
N1 - Funding Information:
3D Figure was constructed in trueSpace 7.6. This work was supported by grants from Karolinska Institutet , Biovitrum, Novo Nordisk Foundation , the Swedish Research Council , the Swedish Diabetes Association , EFSD , the Family Erling-Persson Foundation , Berth von Kantzow's Foundation and EuroDia ( LSHMCT-2006-518153 ) Torsten and Ragnar Söderberg's Foundation , the Knut and Alice Wallenberg Foundation , VIBRANT ( FP7-228933-2 ), Skandia Insurance Company, Ltd. , Strategic Research Program in Diabetes at Karolinska Institutet , the Stichting af Jochnick Foundation and the World Class University program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( CR31-2008-000-10105-0 ).
PY - 2012/9
Y1 - 2012/9
N2 - In a previous review for Advances in Enzyme Research (Berggren and Barker, 2008) we outlined the history of our involvement in discovering important roles for inositides in the insulin secreting pancreatic beta cell. In this current appraisal we bring the work up to date and project how we believe this field will continue to develop in the future. Recently, we have seen an important synergism between the growth in our understanding of inositide function and our knowledge of beta cell stimulus-secretion coupling in both physiological and pathophysiological contexts. Important advances have been made in three areas. 1. The classic regulation of cytoplasmic free Ca2+ concentration [Ca2+]i by Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and its receptor, 2. A novel role of the inositol pyrophosphates, especially 5-diphosphoinositol pentakisphosphate (5-PP-InsP5), in exocytosis, and 3. The unique signaling roles of PI3K pathways instituted by the engagement of the insulin receptor in an autocrine, positive feed-back loop. We examine each of these in turn and close with an assessment of the likely future directions the research will take.
AB - In a previous review for Advances in Enzyme Research (Berggren and Barker, 2008) we outlined the history of our involvement in discovering important roles for inositides in the insulin secreting pancreatic beta cell. In this current appraisal we bring the work up to date and project how we believe this field will continue to develop in the future. Recently, we have seen an important synergism between the growth in our understanding of inositide function and our knowledge of beta cell stimulus-secretion coupling in both physiological and pathophysiological contexts. Important advances have been made in three areas. 1. The classic regulation of cytoplasmic free Ca2+ concentration [Ca2+]i by Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and its receptor, 2. A novel role of the inositol pyrophosphates, especially 5-diphosphoinositol pentakisphosphate (5-PP-InsP5), in exocytosis, and 3. The unique signaling roles of PI3K pathways instituted by the engagement of the insulin receptor in an autocrine, positive feed-back loop. We examine each of these in turn and close with an assessment of the likely future directions the research will take.
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U2 - 10.1016/j.jbior.2012.05.002
DO - 10.1016/j.jbior.2012.05.002
M3 - Review article
C2 - 22884029
AN - SCOPUS:84864571029
VL - 52
SP - 361
EP - 368
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
SN - 2212-4926
IS - 3
ER -