Abstract
A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-471 |
| Number of pages | 5 |
| Journal | Cell and Tissue Research |
| Volume | 240 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1 1985 |
| Externally published | Yes |
Keywords
- CRF immunohistology
- Electron microscopy
- Paraventricular nuclei
- Pituitary gland, pars nervosa
- Rat
ASJC Scopus subject areas
- Anatomy
- Clinical Biochemistry
- Cell Biology
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Cite this
Lengvári, I., Liposits, Z., Vigh, S., Schally, A. V., & Flerkó, B. (1985). The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat. Cell and Tissue Research, 240(2), 467-471. https://doi.org/10.1007/BF00222361