Abstract
A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels.
Original language | English (US) |
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Pages (from-to) | 467-471 |
Number of pages | 5 |
Journal | Cell and Tissue Research |
Volume | 240 |
Issue number | 2 |
DOIs | |
State | Published - May 1 1985 |
Externally published | Yes |
Keywords
- CRF immunohistology
- Electron microscopy
- Paraventricular nuclei
- Pituitary gland, pars nervosa
- Rat
ASJC Scopus subject areas
- Anatomy
- Clinical Biochemistry
- Cell Biology