The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat

István Lengvári, Zsolt Liposits, Sándor Vigh, Andrew V. Schally, Béla Flerkó

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels.

Original languageEnglish (US)
Pages (from-to)467-471
Number of pages5
JournalCell and Tissue Research
Volume240
Issue number2
DOIs
StatePublished - May 1 1985
Externally publishedYes

Keywords

  • CRF immunohistology
  • Electron microscopy
  • Paraventricular nuclei
  • Pituitary gland, pars nervosa
  • Rat

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

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