The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat

István Lengvári; Zsolt Liposits; Sándor Vigh; Andrew V. Schally; Béla Flerkó

doi:10.1007/BF00222361

The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat

István Lengvári, Zsolt Liposits, Sándor Vigh, Andrew V. Schally, Béla Flerkó

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels.

Original language	English (US)
Pages (from-to)	467-471
Number of pages	5
Journal	Cell and Tissue Research
Volume	240
Issue number	2
DOIs	https://doi.org/10.1007/BF00222361
State	Published - May 1 1985
Externally published	Yes

Keywords

CRF immunohistology
Electron microscopy
Paraventricular nuclei
Pituitary gland, pars nervosa
Rat

ASJC Scopus subject areas

Anatomy
Clinical Biochemistry
Cell Biology

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The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat. / Lengvári, István; Liposits, Zsolt; Vigh, Sándor; Schally, Andrew V.; Flerkó, Béla.

In: Cell and Tissue Research, Vol. 240, No. 2, 01.05.1985, p. 467-471.

Research output: Contribution to journal › Article › peer-review

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