The Optical Coherence Tomographic Profile of Leber Hereditary Optic Neuropathy

Thomas R. Hedges, Marisa Gobuty, Richard A. Manfready, Natalie Erlich-Malona, Caitlin Monaco, Carlos E. Mendoza-Santiesteban

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time in Leber hereditary optic neuropathy (LHON) patients. Average RNFL and GCC thickness was measured in seven patients in the early acute (123, 68.4 μm), late acute (113.5, 57.4 μm), and chronic (72.7, 50.8 μm) phases. Patients showed thinning of the GCC with RNFL swelling in the early acute phase. GCC thinning became severe within weeks and persisted. RNFL swelling normalised during the late acute phase with eventual thinning in the chronic phase. GCC changes appear at the commencement of visual loss and in some cases prior to vision loss. These findings define an optical coherence tomography (OCT) profile in LHON.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
Issue number3
StatePublished - May 3 2016
Externally publishedYes


  • Ganglion cell complex
  • Leber hereditary optic neuropathy
  • optical coherence tomography
  • retinal nerve fibre layer

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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