Abstract
The ultrastructure of the ocular pigment abnormally of human Chediak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.
| Original language | English |
|---|---|
| Pages (from-to) | 591-596 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Pathology |
| Volume | 75 |
| Issue number | 4 |
| State | Published - Jan 1 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature. / Valenzuela, R.; Morningstar, W. A.
In: American Journal of Clinical Pathology, Vol. 75, No. 4, 01.01.1981, p. 591-596.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature
AU - Valenzuela, R.
AU - Morningstar, W. A.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The ultrastructure of the ocular pigment abnormally of human Chediak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.
AB - The ultrastructure of the ocular pigment abnormally of human Chediak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019433766&partnerID=8YFLogxK
M3 - Article
C2 - 7223721
AN - SCOPUS:0019433766
VL - 75
SP - 591
EP - 596
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 4
ER -