The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature

R. Valenzuela, W. A. Morningstar

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The ultrastructure of the ocular pigment abnormally of human Chediak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.

Original languageEnglish
Pages (from-to)591-596
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume75
Issue number4
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Chediak-Higashi Syndrome
Organelles
Electrons
Melanosomes
Light
Neural Crest
Melanocytes
Lysosomes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature. / Valenzuela, R.; Morningstar, W. A.

In: American Journal of Clinical Pathology, Vol. 75, No. 4, 01.01.1981, p. 591-596.

Research output: Contribution to journalArticle

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