The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature

R. Valenzuela, W. A. Morningstar

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The ultrastructure of the ocular pigment abnormally of human Chediak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalAmerican journal of clinical pathology
Volume75
Issue number4
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'The ocular pigmentary disturbance of human Chediak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature'. Together they form a unique fingerprint.

  • Cite this