The occurrence of serine phosphate in glycogenin: A possible regulatory site

J. Lomako, W. J. Whelan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Glycogenin is the covalently bound protein found in muscle glycogen that it thought to be the primer for glycogen synthesis. We now report that glycogenin contains a phosphoserine residue. From a less than stoichiometric amount of phosphate in glycogenin as isolated, the content may be increased to one molecular proportion, using the catalytic subunit of cAMP-dependent protein kinase. The phosphoserine residue is present within a hitherto-undescribed amino acid sequence. In particular, the serine is not flanked by arginine, previously thought to be an essential adjunct for a serine residue to act as substrate for this kinase. We suggest that the serine phosphate may represent a means of regulating the ability of glycogenin to prime glycogen synthesis.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry


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