The occurrence of serine phosphate in glycogenin: A possible regulatory site

Research output: Contribution to journalArticle

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Abstract

Glycogenin is the covalently bound protein found in muscle glycogen that it thought to be the primer for glycogen synthesis. We now report that glycogenin contains a phosphoserine residue. From a less than stoichiometric amount of phosphate in glycogenin as isolated, the content may be increased to one molecular proportion, using the catalytic subunit of cAMP-dependent protein kinase. The phosphoserine residue is present within a hitherto-undescribed amino acid sequence. In particular, the serine is not flanked by arginine, previously thought to be an essential adjunct for a serine residue to act as substrate for this kinase. We suggest that the serine phosphate may represent a means of regulating the ability of glycogenin to prime glycogen synthesis.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalBioFactors
Volume1
Issue number3
StatePublished - Jan 1 1988

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Phosphoserine
Glycogen
Serine
Cyclic AMP-Dependent Protein Kinases
Arginine
Muscle
Amino Acid Sequence
Catalytic Domain
Phosphotransferases
Phosphates
Amino Acids
Muscles
glycogenin
Substrates
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

The occurrence of serine phosphate in glycogenin : A possible regulatory site. / Lomako, J.; Whelan, William J.

In: BioFactors, Vol. 1, No. 3, 01.01.1988, p. 261-264.

Research output: Contribution to journalArticle

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