The occurrence of serine phosphate in glycogenin: A possible regulatory site

J. Lomako, W. J. Whelan

Research output: Contribution to journalArticle

15 Scopus citations


Glycogenin is the covalently bound protein found in muscle glycogen that it thought to be the primer for glycogen synthesis. We now report that glycogenin contains a phosphoserine residue. From a less than stoichiometric amount of phosphate in glycogenin as isolated, the content may be increased to one molecular proportion, using the catalytic subunit of cAMP-dependent protein kinase. The phosphoserine residue is present within a hitherto-undescribed amino acid sequence. In particular, the serine is not flanked by arginine, previously thought to be an essential adjunct for a serine residue to act as substrate for this kinase. We suggest that the serine phosphate may represent a means of regulating the ability of glycogenin to prime glycogen synthesis.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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