Abstract
The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-178 |
| Number of pages | 8 |
| Journal | Experimental and Molecular Pathology |
| Volume | 71 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2001 |
| Externally published | Yes |
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Keywords
- Baldness
- Hfh11
- nu
- Skin
- Whn
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Clinical Biochemistry
Cite this
The nude mouse skin phenotype : The role of Foxn1 in hair follicle development and cycling. / Mecklenburg, Lars; Nakamura, Motonobu; Paus, Ralf; Mecklenburg, Lars; Sundberg, John P.
In: Experimental and Molecular Pathology, Vol. 71, No. 2, 01.01.2001, p. 171-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The nude mouse skin phenotype
T2 - The role of Foxn1 in hair follicle development and cycling
AU - Mecklenburg, Lars
AU - Nakamura, Motonobu
AU - Paus, Ralf
AU - Mecklenburg, Lars
AU - Sundberg, John P.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.
AB - The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.
KW - Baldness
KW - Hfh11
KW - nu
KW - Skin
KW - Whn
UR - http://www.scopus.com/inward/record.url?scp=0034770495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034770495&partnerID=8YFLogxK
U2 - 10.1006/exmp.2001.2386
DO - 10.1006/exmp.2001.2386
M3 - Article
C2 - 11599924
AN - SCOPUS:0034770495
VL - 71
SP - 171
EP - 178
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
SN - 0014-4800
IS - 2
ER -