The nude mouse skin phenotype: The role of Foxn1 in hair follicle development and cycling

Lars Mecklenburg; Motonobu Nakamura; Ralf Paus; Lars Mecklenburg; John P. Sundberg

doi:10.1006/exmp.2001.2386

The nude mouse skin phenotype: The role of Foxn1 in hair follicle development and cycling

Lars Mecklenburg, Motonobu Nakamura, Ralf Paus, Lars Mecklenburg, John P. Sundberg

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.

Original language	English (US)
Pages (from-to)	171-178
Number of pages	8
Journal	Experimental and Molecular Pathology
Volume	71
Issue number	2
DOIs	https://doi.org/10.1006/exmp.2001.2386
State	Published - Jan 1 2001
Externally published	Yes

Keywords

Baldness
Hfh11
Skin
Whn
nu

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Clinical Biochemistry

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