The nude mouse skin phenotype: The role of Foxn1 in hair follicle development and cycling

Lars Mecklenburg, Motonobu Nakamura, Ralf Paus, Lars Mecklenburg, John P. Sundberg

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalExperimental and Molecular Pathology
Volume71
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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Keywords

  • Baldness
  • Hfh11
  • Skin
  • Whn
  • nu

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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