TY - JOUR
T1 - The nodes of ranvier in the nerves of mice with muscular dystrophy
AU - Bradley, Walter G.
AU - Jaros, Evelyn
AU - Jenkison, Margaret
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1977
Y1 - 1977
N2 - Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.
AB - Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.
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U2 - 10.1097/00005072-197709000-00003
DO - 10.1097/00005072-197709000-00003
M3 - Article
C2 - 894325
AN - SCOPUS:0017707196
VL - 36
SP - 797
EP - 806
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
SN - 0022-3069
IS - 5
ER -