The nodes of ranvier in the nerves of mice with muscular dystrophy

Walter G. Bradley; Evelyn Jaros; Margaret Jenkison

doi:10.1097/00005072-197709000-00003

The nodes of ranvier in the nerves of mice with muscular dystrophy

Walter G. Bradley, Evelyn Jaros, Margaret Jenkison

Neurology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.

Original language	English (US)
Pages (from-to)	797-806
Number of pages	10
Journal	Journal of neuropathology and experimental neurology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1097/00005072-197709000-00003
State	Published - 1977

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

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title = "The nodes of ranvier in the nerves of mice with muscular dystrophy",

abstract = "Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.",

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AU - Jaros, Evelyn

AU - Jenkison, Margaret

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AB - Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.

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