Abstract
Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.
| Original language | English |
|---|---|
| Pages (from-to) | 797-806 |
| Number of pages | 10 |
| Journal | Journal of Neuropathology and Experimental Neurology |
| Volume | 36 |
| Issue number | 5 |
| State | Published - Dec 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Neuroscience(all)
Cite this
The nodes of Ranvier in the nerves of mice with muscular dystrophy. / Bradley, Walter G; Jaros, E.; Jenkison, M.
In: Journal of Neuropathology and Experimental Neurology, Vol. 36, No. 5, 01.12.1977, p. 797-806.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The nodes of Ranvier in the nerves of mice with muscular dystrophy
AU - Bradley, Walter G
AU - Jaros, E.
AU - Jenkison, M.
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.
AB - Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017707196&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 797
EP - 806
JO - American Journal of Psychotherapy
JF - American Journal of Psychotherapy
SN - 0002-9564
IS - 5
ER -