The nodes of ranvier in the nerves of mice with muscular dystrophy

Walter G. Bradley, Evelyn Jaros, Margaret Jenkison

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Light microscopic, and scanning and transmission electron microscopic studies of the nodes of Ranvier of the distal peripheral nerves of mice with muscular dystrophy (dy/dy) are reported. Extensive widening of the nodes, retraction of Schwann cell cytoplasm and myelin, paranodal thinning of the myelin sheaths, and loss of nodal gap substance were observed. There was no loss of myelinated fibrers. The changes at the nodes of Ranvier probably explain the slowed maximum conduction velocity observed in dystrophic peripheral nerves.

Original languageEnglish (US)
Pages (from-to)797-806
Number of pages10
JournalJournal of neuropathology and experimental neurology
Volume36
Issue number5
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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