Fresh-frozen human liver tissue was assayed for its ability to reduce the nitrogroup of RNO2 to the amine. All 10 livers examined exhibited demonstrable reductase activity. The reduction was potentiated by NADPH and abolished by boiling the liver homogenates. The nitroreductase activity varied among the different livers by as much as severalfold. These findings show the ability of the human liver to reduce RNO2 and support the hypothesis that certain toxic intermediates of the nitroreduction of RNO2 may be responsible for the aplastic anemia associated with this drug.
|Original language||English (US)|
|Number of pages||6|
|Journal||The Journal of Laboratory and Clinical Medicine|
|State||Published - Jun 1981|
ASJC Scopus subject areas
- Pathology and Forensic Medicine