The new stem cell biology.

Peter J. Quesenberry, Gerald A. Colvin, Jean Francois Lambert, Angela E. Frimberger, Mark S. Dooner, Christina I. Mcauliffe, Caroline Miller, Pamela Becker, Evangelis Badiavas, Vincent J. Falanga, Gerald Elfenbein, Lawrence G. Lum

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Recent studies have indicated that bone marrow stem cells are capable of generating muscle, cardiac, hepatic, renal, and bone cells. Purified hematopoietic stem cells have generated cardiac and hepatic cells and reversed disease manifestations in these tissues. Hematopoietic stem cells also alter phenotype with cell cycle transit or circadian phase. During a cytokine stimulated cell cycle transit, reversible alterations of differentiation and engraftment occur. Primitive hematopoietic stem cells express a wide variety of adhesion and cytokine receptors and respond quickly with migration and podia extensions on exposure to cytokines. These data suggest an "Open Chromatin" model of stem cell regulation in which there is a fluctuating continuum in the stem cell/progenitor cell compartments, rather than a hierarchical relationship. These observations, along with progress in using low dose treatments and tolerization approaches, suggest many new therapeutic strategies involving stem cells and the creation of a new medical specialty; stemology.

Original languageEnglish (US)
Pages (from-to)182-206; discussion 206-207
JournalTransactions of the American Clinical and Climatological Association
Volume113
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Quesenberry, P. J., Colvin, G. A., Lambert, J. F., Frimberger, A. E., Dooner, M. S., Mcauliffe, C. I., Miller, C., Becker, P., Badiavas, E., Falanga, V. J., Elfenbein, G., & Lum, L. G. (2002). The new stem cell biology. Transactions of the American Clinical and Climatological Association, 113, 182-206; discussion 206-207.