The new immunosuppressive era

A. I. Lo Monte, Gaetano Ciancio, George W Burke, David Roth, J. Miller

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Immunosuppression, although necessary to enable the graft to escape the consequence of immune surveillance carries some risks for the patients. There is an associated increase in neoplasm, opportunistic infections, and end-organ toxicity. In addition, even with excellent patient compliance, rejection (acute and chronic) remain a major limitation that contributes to the loss or decrease in the Junction of the allograft. New drugs have been added to the armamentarium of immunosuppressive agents to suppress allograft rejection and to rescue graft from cyclosporine-resistant. Most of the immunosuppressive agents in use today are direct at the T lymphocyte, non-specifically inhibiting T-cell activation and proliferation. The authors described here an update of these new immunosuppressive agents and new strategies used in solid organ transplantation.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalAnnali Italiani di Chirurgia
Volume70
Issue number1
StatePublished - Jan 1 1999

Fingerprint

Immunosuppressive Agents
Allografts
T-Lymphocytes
Transplants
Opportunistic Infections
Organ Transplantation
Patient Compliance
Immunosuppression
Cyclosporine
Cell Proliferation
Pharmaceutical Preparations
Neoplasms
Rejection (Psychology)

Keywords

  • Bone marrow
  • Chimerism
  • Immunosuppressive agents
  • Organ transplantation
  • Rejection
  • Tolerance

ASJC Scopus subject areas

  • Surgery

Cite this

The new immunosuppressive era. / Lo Monte, A. I.; Ciancio, Gaetano; Burke, George W; Roth, David; Miller, J.

In: Annali Italiani di Chirurgia, Vol. 70, No. 1, 01.01.1999, p. 1-19.

Research output: Contribution to journalArticle

Lo Monte, AI, Ciancio, G, Burke, GW, Roth, D & Miller, J 1999, 'The new immunosuppressive era', Annali Italiani di Chirurgia, vol. 70, no. 1, pp. 1-19.
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